Gamma hydroxybutyric acid (ghb) for the treatment of alcohol dependence: A review
Open accessAbstract
Gamma-hydroxybutyric acid (GHB) is a short-chain fatty acid structurally similar to the inhibitory neurotransmitter gamma-aminobutyric acid. Clinical trials have demonstrated that 50-100 mg/kg of GHB fractioned into three or six daily doses is able to suppress alcohol withdrawal symptoms and facilitates the maintenance of abstinence from alcohol. These studies have also shown that GHB craving episodes are a very limited phenomenon (about 10-15%). Thus, physicians with access should consider the clinical efficacy of GHB as a valid pharmacological tool for the treatment of alcohol addiction.
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GHB has low binding affinity to GABA-B receptors and high binding affinity to GHB receptors, and GABA-B receptors are believed to be the main drivers of the pharmacological effects of externally administered GHB.
“GHB has a low binding affinity to GABA-B receptors, while it has a high binding affinity to receptors specifically designed for GHB. GABA-B receptors are believed to be the main drivers of the pharmacological effects of externally administered GHB.”
From A Narrative Review of Current and Emerging Trends in the Treatment of Alcohol Use Disorder (2024) · cites this paper as [44]
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References 76 · Cited by 73
- Authors
- Caputo, F., Vignoli, T., Maremmani, I., Bernardi, M., & Zoli, G.
- Affiliations
- Department of Internal Medicine, SS Annunziata Hospital, Cento (Ferrara), Italy
- University of Bologna (IT)
- University of Pisa (IT)
- Corresponding author
- Caputo, Fabio
- Venue
- International Journal of Environmental Research and Public Health
- Publisher
- MDPI AG
- Published
- 2009-06-24
- Volume
- 6
- Issue
- 6
- Pages
- 1917-1929
- ISSN
- 1660-4601 (ISSN-L)
- PMC
- PMC2705225
- OpenAlex
- W1983598011
- Cited by
- 73
- References
- 76
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 5 · 2017: 3 · 2016: 4 · 2015: 5 · 2014: 10 · 2013: 10 · 2012: 7
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Environmental Research and Public Health (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Neurology › Alcoholism and Thiamine Deficiency
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- gamma-hydroxybutyric acid, alcoholism, alcohol withdrawal symptoms, alcohol craving, GABA analogues
- MeSH terms
- Alcoholism, Humans, Hydroxybutyrates, Motivation, Substance Withdrawal Syndrome, Randomized Controlled Trials as Topic
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