Antioxidant and cytotoxic activities of Centella asiatica (L) Urb
Open accessAbstract
In the present study, the phenolic (Folin-Dennis) and flavonoid (colorimetric assay) constituents, antioxidant [2,2-diphenyl-2-picrylhydrazyl hydrate (DPPH) assay] and cytotoxic activities of an aqueous extract (AE) of Centella asiatica leaves were investigated. The aqueous extract (50 g/L) was obtained by infusion followed by cold maceration for 24 h. The levels of phenolic and flavonoid compounds were 2.86 g/100 g and 0.361 g/100 g, respectively. The AE showed elevated DPPH scavenging activity, with an IC(50) value of 31.25 microg/mL. The AE had a promising activity against mouse melanoma (B(16)F(1)), human breast cancer (MDA MB-231) and rat glioma (C(6)) cell lines, with IC(50) values of 698.0, 648.0 and 1000.0 microg/mL, respectively. A positive correlation was established between the level of flavonoids, antioxidant and antitumor activities.
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CA extracts have positive effects on neurite elongation, neurodegeneration, antioxidant activity, and mitochondrial dysfunction.
“CA extracts have demonstrated positive effects on neurite elongation [6], neurodegeneration [29], antioxidant activity [30], and mitochondrial dysfunction [31].”
From Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice (2019) · cites this paper as [30]
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References 122 · Cited by 244
Research works printed but not linked: 2
- [6]Coelho MG Cheddier LM Scio E Pimenta DS Alterações morfoanatômicas e químicas em Centella erecta (Linn. F.) Fernand., relacionadas à luminosidade e sazonalidade Proceedings of Livro de resumos XI Seminário Mineiro de Plantas Medicinais e IIa Jornada de Farmácia de Diamantina Diamantina, Brazil 2005 81 82
- [37]Wiltshaw E Roberts JJ Carr B Recents Results in Cancer Research Platinum Coordination Complexes in Cancer Chemotherapy Springer-Verlag New York, NY, USA 1974 178
- Authors
- Pittella, F., Dutra, R. C., Junior, D. D., Lopes, M. T. P., & Barbosa, N. R.
- Affiliations
- Universidade Federal de Juiz de Fora (BR)
- Laboratório de Substâncias Antitumorais, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, CEP 31270-901, Belo Horizonte, MG, Brazil
- Corresponding author
- Barbosa, Nádia R.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2009-08-26
- Volume
- 10
- Issue
- 9
- Pages
- 3713-3721
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC2769141
- OpenAlex
- W2033327918
- Cited by
- 244
- References
- 122
- Citations by year
- 2026: 8 · 2025: 17 · 2024: 15 · 2023: 23 · 2022: 22 · 2021: 24 · 2020: 13 · 2019: 21 · 2018: 19 · 2017: 13 · 2016: 13 · 2015: 11 · 2014: 14 · 2013: 14 · 2012: 9
- FWCI
- 13.03
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Universidade Federal de Juiz de Fora
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Keywords
- Centella asiatica, antioxidant activity, cytotoxicity, phenolic compounds, flavonoids, DPPH radical scavenging, aqueous leaf extract, anticancer activity, melanoma, breast cancer, glioma
- MeSH terms
- Animals, Antineoplastic Agents, Phytogenic, Biphenyl Compounds, Drug Screening Assays, Antitumor, Flavonoids, Free Radicals, Humans, Phenols, Picrates, Plant Extracts, Free Radical Scavengers, Plant Leaves, Inhibitory Concentration 50, Centella, Cell Line, Tumor, Mice, Rats
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