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Disease Resistance Gene Analogs (RGAs) in Plants

Open access
Sekhwal, Manoj, Li, Pingchuan, Lam, Irene, Wang, Xiue, Cloutier, Sylvie, You, Frank·2015·International Journal of Molecular Sciences

Abstract

Plants have developed effective mechanisms to recognize and respond to infections caused by pathogens. Plant resistance gene analogs (RGAs), as resistance (R) gene candidates, have conserved domains and motifs that play specific roles in pathogens’ resistance. Well-known RGAs are nucleotide binding site leucine rich repeats, receptor like kinases, and receptor like proteins. Others include pentatricopeptide repeats and apoplastic peroxidases. RGAs can be detected using bioinformatics tools based on their conserved structural features. Thousands of RGAs have been identified from sequenced plant genomes. High-density genome-wide RGA genetic maps are useful for designing diagnostic markers and identifying quantitative trait loci (QTL) or markers associated with plant disease resistance. This review focuses on recent advances in structures and mechanisms of RGAs, and their identification from sequenced genomes using bioinformatics tools. Applications in enhancing fine mapping and cloning of plant disease resistance genes are also discussed.

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Crossref · 10.3390/ijms160819248

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Metadata

Authors
Sekhwal, M., Li, P., Lam, I., Wang, X., Cloutier, S., & You, F.
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2015-08-14
Volume
16
Issue
8
Pages
19248-19290
ISSN
1422-0067 (ISSN-L)
OpenAlex
W1774067764
Cited by
327
References
7
FWCI
26.30
Type
journal article
Language
en
Open access
gold

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