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Heavy Metal Induced Antibiotic Resistance in Bacterium LSJC7

Chen, Songcan, Li, Xiaomin, Sun, Guoxin, Zhang, Yingjiao, Su, Jianqiang, Ye, Jun·2015·International Journal of Molecular Sciences
DOI 10.3390/ijms161023390
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Abstract

Co-contamination of antibiotics and heavy metals prevails in the environment, and may play an important role in disseminating bacterial antibiotic resistance, but the selective effects of heavy metals on bacterial antibiotic resistance is largely unclear. To investigate this, the effects of heavy metals on antibiotic resistance were studied in a genome-sequenced bacterium, LSJC7. The results showed that the presence of arsenate, copper, and zinc were implicated in fortifying the resistance of LSJC7 towards tetracycline. The concentrations of heavy metals required to induce antibiotic resistance, i.e., the minimum heavy metal concentrations (MHCs), were far below (up to 64-fold) the minimum inhibition concentrations (MIC) of LSJC7. This finding indicates that the relatively low heavy metal levels in polluted environments and in treated humans and animals might be sufficient to induce bacterial antibiotic resistance. In addition, heavy metal induced antibiotic resistance was also observed for a combination of arsenate and chloramphenicol in LSJC7, and copper/zinc and tetracycline in antibiotic susceptible strain Escherichia coli DH5α. Overall, this study implies that heavy metal induced antibiotic resistance might be ubiquitous among various microbial species and suggests that it might play a role in the emergence and spread of antibiotic resistance in metal and antibiotic co-contaminated environments.

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  • Pollution with heavy metals such as chromium, lead, cadmium, and mercury is well-documented to induce antibiotic resistance through co-selection.

    “Moreover, pollution with heavy metals such as chromium, lead, cadmium, and mercury is well-documented to induce antibiotic resistance through co-selection10–12.”

    From Impact of untreated tannery wastewater in the evolution of multidrug-resistant bacteria in Bangladesh (2024) · cites this paper as [11]

    The Introduction (page unavailable) describes heavy-metal contamination contributing to antibiotic resistance and reports that cadmium increased resistance in microcosms. But the paper's own antibiotic-resistance findings concern arsenate, copper, and zinc; our copy does not establish that chromium, lead, or mercury induce antibiotic resistance through co-selection. (LLM, conf=0.87)

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Metadata

Authors
Chen, S., Li, X., Sun, G., Zhang, Y., Su, J., & Ye, J.
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2015-09-29
Volume
16
Issue
10
Pages
23390-23404
ISSN
1422-0067
DOI
10.3390/ijms161023390
Cited by
128
References
1
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
National Natural Science Foundation of China (21210008, 41430858)

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