The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The Role of Sialyl-Tn in Cancer
Open accessAbstract
Activation of an aberrant glycosylation pathway in cancer cells can lead to expression of the onco-foetal sialyl-Tn (sTn) antigen. STn is a truncated O-glycan containing a sialic acid α-2,6 linked to GalNAc α-O-Ser/Thr and is associated with an adverse outcome and poor prognosis in cancer patients. The biosynthesis of the sTn antigen has been linked to the expression of the sialytransferase ST6GalNAc1, and also to mutations in and loss of heterozygosity of the COSMC gene. sTn neo- or over-expression occurs in many types of epithelial cancer including gastric, colon, breast, lung, oesophageal, prostate and endometrial cancer. sTn is believed to be carried by a variety of glycoproteins and may influence protein function and be involved in tumour development. This review discusses how the role of sTn in cancer development and tumour cell invasiveness might be organ specific and occur through different mechanisms depending on each cancer type or subtype. As the sTn-antigen is expressed early in carcinogenesis targeting sTn in cancer may enable the targeting of tumours from the earliest stage.
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Cites
Cosmc is an essential chaperone for correct protein O-glycosylation
Wang, Y., Ju, T., Ding, X., Xia, B., Wang, W., Xia, L., He, M., & Cummings, R. D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914004107 · Cited by 212
Schjoldager, K. T.-B. G., & Clausen, H. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.09.014 · Cited by 193
Cited by
Hallmarks of glycosylation in cancer
Munkley, J., & Elliott, D. J. (2016) · Oncotarget · doi:10.18632/oncotarget.8155 · Cited by 521
Self-citationInsights into the role of sialylation in cancer progression and metastasis
Dobie, C., & Skropeta, D. (2021) · British Journal of Cancer · doi:10.1038/s41416-020-01126-7 · Cited by 348
Lee, J.-G., Lee, S., Jeon, J., Kong, H. G., Cho, H.-J., Kim, J.-H., Kim, S.-Y., Oh, M. J., Lee, D., Seo, N., et al. (2022) · Microbiome · doi:10.1186/s40168-021-01191-x · Cited by 26
Glycosylation in cancer: mechanisms, diagnostic markers, and therapeutic applications
Qusairy, Z., & Rada, M. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05303-1 · Cited by 16
Metadata
- Authors
- Munkley, J.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2016-02-24
- Volume
- 17
- Issue
- 3
- Pages
- 275
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2279167407
- Cited by
- 226
- References
- 2
- FWCI
- 6.77
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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