Role of Non-Coding RNAs in the Transgenerational Epigenetic Transmission of the Effects of Reprotoxicants
Open accessAbstract
Non-coding RNAs (ncRNAs) are regulatory elements of gene expression and chromatin structure. Both long and small ncRNAs can also act as inductors and targets of epigenetic programs. Epigenetic patterns can be transmitted from one cell to the daughter cell, but, importantly, also through generations. Diversity of ncRNAs is emerging with new and surprising roles. Functional interactions among ncRNAs and between specific ncRNAs and structural elements of the chromatin are drawing a complex landscape. In this scenario, epigenetic changes induced by environmental stressors, including reprotoxicants, can explain some transgenerationally-transmitted phenotypes in non-Mendelian ways. In this review, we analyze mechanisms of action of reprotoxicants upon different types of ncRNAs and epigenetic modifications causing transgenerationally transmitted characters through germ cells but affecting germ cells and reproductive systems. A functional model of epigenetic mechanisms of transgenerational transmission ncRNAs-mediated is also proposed.
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ncRNAs play a major regulatory role in the epigenetic transgenerational transmission of the effects of reprotoxicants on the development and differentiation of germ cells, and subsequently in reducing mammalian fertility as a result of exposure to environmental pollutants during early development.
“ncRNAs have been studied to play a major regulatory role in the epigenetic transgenerational transmission of the effects of reprotoxicants on the development and differentiation of germ cells, and subsequently, in reducing mammalian fertility as a result of exposure to environmental pollutants during early development [103] (see the review by Larriba y del Mazo 2016).”
From Revisiting Epigenetics Fundamentals and Its Biomedical Implications (2024) · cites this paper as [103]
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References 111 · Cited by 47
Research works printed but not linked: 1
- [4]Wilhelm D. Bernard P. Non-Coding RNA and the Reproductive System Springer Netherlands Dordrecht, The Netherlands 2016
- Authors
- Larriba, E., & Del Mazo, J.
- Affiliations
- Centro de Investigaciones Biológicas Margarita Salas (ES)
- Department of Cellular and Molecular Biology, Centro de Investigaciones Biológicas (CSIC), Ramiro de Maeztu 9, Madrid 28040, Spain
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2016-03-25
- Volume
- 17
- Issue
- 4
- Pages
- 452
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC4848908
- OpenAlex
- W2310421917
- Cited by
- 47
- References
- 111
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 7 · 2023: 7 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 5 · 2017: 7 · 2016: 3
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- MINECO. Spain ((BFU2013-42164-R))
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- non-coding RNA, transgenerational epigenetic inheritance, long non-coding RNA, small RNA, chromatin structure, germ cells, reproductive toxicity, environmental stressors, non-Mendelian inheritance, epigenetic modifications
- MeSH terms
- Histones, Humans, Reproduction, DNA Methylation, RNA, Untranslated, MicroRNAs, Epigenesis, Genetic, Endocrine Disruptors
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