Targeting the tumor microenvironment: the protumor effects of IL-17 related to cancer type
Open accessAbstract
The inflammatory process contributes to immune tolerance as well as to tumor progression and metastasis. By releasing extracellular signals, cancerous cells constantly shape their surrounding microenvironment through their interactions with infiltrating immune cells, stromal cells and components of extracellular matrix. Recently, the pro-inflammatory interleukin 17 (IL-17)-producing T helper lymphocytes, the Th17 cells, and the IL-17/IL-17 receptor (IL-17R) axis gained special attention. The IL-17 family comprises at least six members, IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25), and IL-17F. Secreted as disulfide-linked homo- or heterodimers, the IL-17 bind to the IL-17R, a type I cell surface receptor, of which there are five variants, IL-17RA to IL-17RE. This review focuses on the current advances identifying the promoting role of IL-17 in carcinogenesis, tumor metastasis and resistance to chemotherapy of diverse solid cancers. While underscoring the IL-17/IL-17R axis as promising immunotherapeutic target in the context of cancer managing, this knowledge calls upon further in vitro and in vivo studies that would allow the development and implementation of novel strategies to combat tumors.
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IL-17 blockade has probable implications in promoting tumor growth and metastasis, as reported in the literature.
“Notably, IL-17 blockade and its probable implications in promoting tumor growth and metastasis have been reported in the literature.100,101”
From Autoimmune diseases and immune-checkpoint inhibitors for cancer therapy: Review of the literature and personalized risk-based prevention strategy (2020) · cites this paper as [100]
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References 99 · Cited by 159
- Authors
- Fabre, J., Giustiniani, J., Garbar, C., Antonicelli, F., Merrouche, Y., Bensussan, A., Bagot, M., & Al-Dacak, R.
- Affiliations
- Centre Hospitalier Universitaire Henri-Mondor (FR)
- Institut Jean Godinot, Unicancer, 1 rue du Général Koenig, F-51726 Reims, France
- Institut Jean Godinot (FR)
- Université de Reims Champagne-Ardenne (FR)
- Inserm (FR)
- Université Paris Diderot, Sorbonne Paris Cité, Laboratoire Immunologie Dermatologie & Oncologie, UMR-S 976, F-75475 Paris, France
- Corresponding author
- Fabre, Joseph
- Bensussan, Armand
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2016-08-30
- Volume
- 17
- Issue
- 9
- Pages
- 1433
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC5037712
- OpenAlex
- W2517512205
- Cited by
- 159
- References
- 99
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 10 · 2023: 20 · 2022: 20 · 2021: 13 · 2020: 22 · 2019: 16 · 2018: 21 · 2017: 15 · 2016: 1
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- IL-17, tumor microenvironment, Th17 cells, IL-17 family, carcinogenesis, metastasis, chemoresistance, solid tumors, immunotherapy targets, inflammation and cancer
- MeSH terms
- Animals, T-Lymphocytes, Helper-Inducer, Humans, Immunotherapy, Neoplasms, Interleukin-17, Tumor Microenvironment
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