The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.
Tools for Sequence-Based miRNA Target Prediction: What to Choose?
Open accessAbstract
MicroRNAs (miRNAs) are defined as small non-coding RNAs ~22 nt in length. They regulate gene expression at a post-transcriptional level through complementary base pairing with the target mRNA, leading to mRNA degradation and therefore blocking translation. In the last decade, the dysfunction of miRNAs has been related to the development and progression of many diseases. Currently, researchers need a method to identify precisely the miRNA targets, prior to applying experimental approaches that allow a better functional characterization of miRNAs in biological processes and can thus predict their effects. Computational prediction tools provide a rapid method to identify putative miRNA targets. However, since a large number of tools for the prediction of miRNA:mRNA interactions have been developed, all with different algorithms, the biological researcher sometimes does not know which is the best choice for his study and many times does not understand the bioinformatic basis of these tools. This review describes the biological fundamentals of these prediction tools, characterizes the main sequence-based algorithms, and offers some insights into their uses by biologists.
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Cites
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Cited by
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Metadata
- Authors
- Riffo-Campos, Á., Riquelme, I., & Brebi-Mieville, P.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2016-12-09
- Volume
- 17
- Issue
- 12
- Pages
- 1987
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2560678530
- Cited by
- 432
- References
- 107
- FWCI
- 10.55
- Type
- journal article
- Language
- en
- Open access
- gold
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- Riffo-Campos, Á., Riquelme, I., & Brebi-Mieville, P. (2016). Tools for Sequence-Based miRNA Target Prediction: What to Choose? International Journal of Molecular Sciences. https://doi.org/10.3390/ijms17121987
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