The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.
Dry Eye Management: Targeting the Ocular Surface Microenvironment
Open accessAbstract
Dry eye can damage the ocular surface and result in mild corneal epithelial defect to blinding corneal pannus formation and squamous metaplasia. Significant progress in the treatment of dry eye has been made in the last two decades; progressing from lubricating and hydrating the ocular surface with artificial tear to stimulating tear secretion; anti-inflammation and immune regulation. With the increase in knowledge regarding the pathophysiology of dry eye, we propose in this review the concept of ocular surface microenvironment. Various components of the microenvironment contribute to the homeostasis of ocular surface. Compromise in one or more components can result in homeostasis disruption of ocular surface leading to dry eye disease. Complete evaluation of the microenvironment component changes in dry eye patients will not only lead to appropriate diagnosis, but also guide in timely and effective clinical management. Successful treatment of dry eye should be aimed to restore the homeostasis of the ocular surface microenvironment.
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Cites
(2007) · The Ocular Surface · doi:10.1016/s1542-0124(12)70081-2 · Cited by 3,267
Corneal nerves: structure, contents and function
Müller, L. J., Marfurt, C. F., Kruse, F., & Tervo, T. M. T. (2003) · Experimental Eye Research · doi:10.1016/s0014-4835(03)00050-2 · Cited by 1,220
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How corticosteroids control inflammation: Quintiles Prize Lecture 2005
Barnes, P. J. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706736 · Cited by 838
The Pathology of Dry Eye: The Interaction Between the Ocular Surface and Lacrimal Glands
Stern, M. E., Beuerman, R. W., Fox, R. I., Gao, J., Mircheff, A. K., & Pflugfelder, S. C. (1998) · Cornea · doi:10.1097/00003226-199811000-00002 · Cited by 811
VEGFs and receptors involved in angiogenesis versus lymphangiogenesis
Lohela, M., Bry, M., Tammela, T., & Alitalo, K. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.12.012 · Cited by 738
The role of the lacrimal functional unit in the pathophysiology of dry eye
Stern, M. E., Gao, J., Siemasko, K. F., Beuerman, R. W., & Pflugfelder, S. C. (2004) · Experimental Eye Research · doi:10.1016/j.exer.2003.09.003 · Cited by 577
(2007) · The Ocular Surface · doi:10.1016/s1542-0124(12)70085-x · Cited by 565
Neural regulation of lacrimal gland secretory processes: Relevance in dry eye diseases
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Metadata
- Authors
- Zhang, X., M, V. J., Qu, Y., He, X., Ou, S., Bu, J., Jia, C., Wang, J., Wu, H., Liu, Z., & Li, W.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2017-06-29
- Volume
- 18
- Issue
- 7
- Pages
- 1398
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2724132216
- Cited by
- 267
- References
- 122
- FWCI
- 12.02
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zhang, X., M, V. J., Qu, Y., He, X., Ou, S., Bu, J., Jia, C., Wang, J., Wu, H., Liu, Z., & Li, W. (2017). Dry Eye Management: Targeting the Ocular Surface Microenvironment. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms18071398
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