The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Taxol®: The First Microtubule Stabilizing Agent
Open accessAbstract
Taxol®, an antitumor drug with significant activity, is the first microtubule stabilizing agent described in the literature. This short review of the mechanism of action of Taxol® emphasizes the research done in the Horwitz’ laboratory. It discusses the contribution of photoaffinity labeled analogues of Taxol® toward our understanding of the binding site of the drug on the microtubule. The importance of hydrogen/deuterium exchange experiments to further our insights into the stabilization of microtubules by Taxol® is addressed. The development of drug resistance, a major problem that arises in the clinic, is discussed. Studies describing differential drug binding to distinct β-tubulin isotypes are presented. Looking forward, it is suggested that the β-tubulin isotype content of a tumor may influence its responses to Taxol®.
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Cites
Multidrug resistance in cancer: role of ATP–dependent transporters
Gottesman, M. M., Fojo, T., & Bates, S. E. (2002) · Nature Reviews Cancer · doi:10.1038/nrc706 · Cited by 5,536
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Promotion of microtubule assembly in vitro by taxol
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Self-citationStructure of the αβ tubulin dimer by electron crystallography
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Taxol stabilizes microtubules in mouse fibroblast cells.
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Self-citationMicrotubules and resistance to tubulin-binding agents
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Self-citationTaxol binds to polymerized tubulin in vitro
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Metadata
- Authors
- Yang, C.-P., & Horwitz, S.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2017-08-09
- Volume
- 18
- Issue
- 8
- Pages
- 1733
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2744422984
- Cited by
- 284
- References
- 68
- FWCI
- 6.97
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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