The DOI matches its Crossref record; 134 of the 134 references it cites were found in a registry or an index.
Mesenchymal Stem Cells: Cell Fate Decision to Osteoblast or Adipocyte and Application in Osteoporosis Treatment
Open accessAbstract
Osteoporosis is a progressive skeletal disease characterized by decreased bone mass and degraded bone microstructure, which leads to increased bone fragility and risks of bone fracture. Osteoporosis is generally age related and has become a major disease of the world. Uncovering the molecular mechanisms underlying osteoporosis and developing effective prevention and therapy methods has great significance for human health. Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiating into osteoblasts, adipocytes, or chondrocytes, and have become the favorite source of cell-based therapy. Evidence shows that during osteoporosis, a shift of the cell differentiation of MSCs to adipocytes rather than osteoblasts partly contributes to osteoporosis. Thus, uncovering the molecular mechanisms of the osteoblast or adipocyte differentiation of MSCs will provide more understanding of MSCs and perhaps new methods of osteoporosis treatment. The MSCs have been applied to both preclinical and clinical studies in osteoporosis treatment. Here, we review the recent advances in understanding the molecular mechanisms regulating osteoblast differentiation and adipocyte differentiation of MSCs and highlight the therapeutic application studies of MSCs in osteoporosis treatment. This will provide researchers with new insights into the development and treatment of osteoporosis.
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Cited by
Current Status of the Diagnosis and Management of Osteoporosis
Aibar-Almazán, A., Voltes-Martínez, A., Castellote-Caballero, Y., Afanador-Restrepo, D. F., Carcelén-Fraile, M. D. C., & López-Ruiz, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169465 · Cited by 412
Senile Osteoporosis: The Involvement of Differentiation and Senescence of Bone Marrow Stromal Cells
Qadir, A., Liang, S., Wu, Z., Chen, Z., Hu, L., & Qian, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21010349 · Cited by 268
Self-citationAdvances in mesenchymal stem cell transplantation for the treatment of osteoporosis
Jiang, Y., Zhang, P., Zhang, X., Lv, L., & Zhou, Y. (2021) · Cell Proliferation · doi:10.1111/cpr.12956 · Cited by 265
Prakash, N., Kim, J., Jeon, J., Kim, S., Arai, Y., Bello, A. B., Park, H., & Lee, S.-H. (2023) · Biomaterials Research · doi:10.1186/s40824-023-00371-0 · Cited by 56
Metadata
- Authors
- Hu, L., Yin, C., Zhao, F., Ali, A., Ma, J., & Qian, A.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2018-01-25
- Volume
- 19
- Issue
- 2
- Pages
- 360
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2793880258
- Cited by
- 431
- References
- 134
- FWCI
- 17.30
- Type
- journal article
- Language
- en
- Open access
- gold
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- Hu, L., Yin, C., Zhao, F., Ali, A., Ma, J., & Qian, A. (2018). Mesenchymal Stem Cells: Cell Fate Decision to Osteoblast or Adipocyte and Application in Osteoporosis Treatment. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms19020360
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