The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Exosomes Derived from Human Induced Pluripotent Stem Cells Ameliorate the Aging of Skin Fibroblasts
Open accessAbstract
Stem cells and their paracrine factors have emerged as a resource for regenerative medicine. Many studies have shown the beneficial effects of paracrine factors secreted from adult stem cells, such as exosomes, on skin aging. However, to date, few reports have demonstrated the use of exosomes derived from human pluripotent stem cells for the treatment of skin aging. In this study, we collected exosomes from the conditioned medium of human induced pluripotent stem cells (iPSCs) and investigated the effect on aged human dermal fibroblasts (HDFs). Cell proliferation and viability were determined by an MTT assay and cell migration capacity was shown by a scratch wound assay and a transwell migration assay. To induce photoaging and natural senescence, HDFs were irradiated by UVB (315 nm) and subcultured for over 30 passages, respectively. The expression level of certain mRNAs was evaluated by quantitative real-time PCR (qPCR). Senescence-associated-β-galactosidase (SA-β-Gal) activity was assessed as a marker of natural senescence. As a result, we found that exosomes derived from human iPSCs (iPSCs-Exo) stimulated the proliferation and migration of HDFs under normal conditions. Pretreatment with iPSCs-Exo inhibited the damages of HDFs and overexpression of matrix-degrading enzymes (MMP-1/3) caused by UVB irradiation. The iPSCs-Exo also increased the expression level of collagen type I in the photo-aged HDFs. In addition, we demonstrated that iPSCs-Exo significantly reduced the expression level of SA-β-Gal and MMP-1/3 and restored the collagen type I expression in senescent HDFs. Taken together, it is anticipated that these results suggest a therapeutic potential of iPSCs-Exo for the treatment of skin aging.
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Self-citationA biomarker that identifies senescent human cells in culture and in aging skin in vivo.
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Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
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Mechanisms of photoaging and chronological skin aging
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Senescence-associated β-galactosidase is lysosomal β-galactosidase.
Lee, B. Y., Han, J. A., Im, J. S., Morrone, A., Johung, K., Goodwin, E. C., Kleijer, W. J., DiMaio, D., & Hwang, E. S. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00199.x · Cited by 1,444
Cited by
Clinical applications of stem cell-derived exosomes
Tan, F., Li, X., Wang, Z., Li, J., Shahzad, K., & Zheng, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01704-0 · Cited by 708
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“In addition, the mean exosome diameter of human induced pluripotent stem cells (iPSCs) was found to be of 86 nm [73] whereas that of both adipose-derived stem cells (ADSCs) and human foreskin fibroblasts averaged 134 and 142 nm, respectively [74].”
Background
Metadata
- Authors
- Oh, M., Lee, J., Kim, Y. J., Rhee, W. J., & Park, J. H.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2018-06-09
- Volume
- 19
- Issue
- 6
- Pages
- 1715
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2807094840
- Cited by
- 257
- References
- 60
- FWCI
- 4.94
- Type
- journal article
- Language
- en
- Open access
- gold
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- Oh, M., Lee, J., Kim, Y. J., Rhee, W. J., & Park, J. H. (2018). Exosomes Derived from Human Induced Pluripotent Stem Cells Ameliorate the Aging of Skin Fibroblasts. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms19061715
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