The DOI matches its Crossref record; 106 of the 106 references it cites were found in a registry or an index.
Reactive Oxygen Species in Osteoclast Differentiation and Possible Pharmaceutical Targets of ROS-Mediated Osteoclast Diseases
Open accessAbstract
Reactive oxygen species (ROS) and free radicals are essential for transmission of cell signals and other physiological functions. However, excessive amounts of ROS can cause cellular imbalance in reduction–oxidation reactions and disrupt normal biological functions, leading to oxidative stress, a condition known to be responsible for the development of several diseases. The biphasic role of ROS in cellular functions has been a target of pharmacological research. Osteoclasts are derived from hematopoietic progenitors in the bone and are essential for skeletal growth and remodeling, for the maintenance of bone architecture throughout lifespan, and for calcium metabolism during bone homeostasis. ROS, including superoxide ion (O2−) and hydrogen peroxide (H2O2), are important components that regulate the differentiation of osteoclasts. Under normal physiological conditions, ROS produced by osteoclasts stimulate and facilitate resorption of bone tissue. Thus, elucidating the effects of ROS during osteoclast differentiation is important when studying diseases associated with bone resorption such as osteoporosis. This review examines the effect of ROS on osteoclast differentiation and the efficacy of novel chemical compounds with therapeutic potential for osteoclast related diseases.
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1 retracted
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Loeser, R. F., Collins, J. A., & Diekman, B. O. (2016) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2016.65 · Cited by 1,290
A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation
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International Journal of Molecular Sciences
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Iantomasi, T., Romagnoli, C., Palmini, G., Donati, S., Falsetti, I., Miglietta, F., Aurilia, C., Marini, F., Giusti, F., & Brandi, M. L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043772 · Cited by 380
Skeletal Aging and Osteoporosis: Mechanisms and Therapeutics
Chandra, A., & Rajawat, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073553 · Cited by 264
Zhou, H., He, Z., Cao, Y., Chu, L., Liang, B., Yu, K., & Deng, Z. (2024) · Theranostics · doi:10.7150/thno.97412 · Cited by 115
The Inflammatory Contribution of B-Lymphocytes and Neutrophils in Progression to Osteoporosis
Frase, D., Lee, C., Nachiappan, C., Gupta, R., & Akkouch, A. (2023) · Cells · doi:10.3390/cells12131744 · Cited by 59
Metadata
- Authors
- Agidigbi, T. S., & Kim, C.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2019-07-22
- Volume
- 20
- Issue
- 14
- Pages
- 3576
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2963301415
- Cited by
- 511
- References
- 106
- FWCI
- 11.89
- Type
- journal article
- Language
- en
- Open access
- gold
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- Agidigbi, T. S., & Kim, C. (2019). Reactive Oxygen Species in Osteoclast Differentiation and Possible Pharmaceutical Targets of ROS-Mediated Osteoclast Diseases. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms20143576
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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