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Chitosan Derivatives and Their Application in Biomedicine
Open accessAbstract
Chitosan is a product of the deacetylation of chitin, which is widely found in nature. Chitosan is insoluble in water and most organic solvents, which seriously limits both its application scope and applicable fields. However, chitosan contains active functional groups that are liable to chemical reactions; thus, chitosan derivatives can be obtained through the chemical modification of chitosan. The modification of chitosan has been an important aspect of chitosan research, showing a better solubility, pH-sensitive targeting, an increased number of delivery systems, etc. This review summarizes the modification of chitosan by acylation, carboxylation, alkylation, and quaternization in order to improve the water solubility, pH sensitivity, and the targeting of chitosan derivatives. The applications of chitosan derivatives in the antibacterial, sustained slowly release, targeting, and delivery system fields are also described. Chitosan derivatives will have a large impact and show potential in biomedicine for the development of drugs in future.
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Cites
Opportunities and challenges in combination gene cancer therapy
Nastiuk, K. L., & Krolewski, J. J. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.12.005 · Cited by 85
Liu, Q., Zhang, C., Zheng, X., Shao, X., Zhang, X., Zhang, Q., & Jiang, X. (2014) · Vaccine · doi:10.1016/j.vaccine.2014.03.041 · Cited by 22
Cited by
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Aibani, N., Rai, R., Patel, P., Cuddihy, G., & Wasan, E. K. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13101686 · Cited by 419
El-Araby, A., Janati, W., Ullah, R., Ercisli, S., & Errachidi, F. (2024) · Frontiers in Chemistry · doi:10.3389/fchem.2023.1327426 · Cited by 280
Chitosan-Based Nanoparticles of Targeted Drug Delivery System in Breast Cancer Treatment
Herdiana, Y., Wathoni, N., Shamsuddin, S., Joni, I. M., & Muchtaridi, M. (2021) · Polymers · doi:10.3390/polym13111717 · Cited by 196
Smart stimuli-responsive hydrogels for drug delivery in periodontitis treatment
Wang, Y., Li, J., Tang, M., Peng, C., Wang, G., Wang, J., Wang, X., Chang, X., Guo, J., & Gui, S. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114688 · Cited by 100
Seyam, S., Nordin, N. A., & Alfatama, M. (2020) · Pharmaceuticals · doi:10.3390/ph13100307 · Cited by 85
Metadata
- Authors
- Wang, W., Meng, Q., Li, Q., Liu, J., Zhou, M., Jin, Z., & Zhao, K.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2020-01-12
- Volume
- 21
- Issue
- 2
- Pages
- 487
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W3000743283
- Cited by
- 982
- References
- 2
- FWCI
- 41.11
- Type
- journal article
- Language
- en
- Open access
- gold
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- Wang, W., Meng, Q., Li, Q., Liu, J., Zhou, M., Jin, Z., & Zhao, K. (2020). Chitosan Derivatives and Their Application in Biomedicine. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms21020487
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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