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Cited by 53MicroRNA in disease regulationRadioactivity and Radon MeasurementsEffects of Radiation Exposure

Radon Biomonitoring and microRNA in Lung Cancer

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Bersimbaev, Rakhmet, Pulliero, Alessandra, Bulgakova, Olga, Kussainova, Assiya, Aripova, Akmara, Izzotti, Alberto·2020·International Journal of Molecular Sciences
DOI 10.3390/ijms21062154PMC PMC7139524
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Abstract

Radon is the number one cause of lung cancer in non-smokers. microRNA expression in human bronchial epithelium cells is altered by radon, with particular reference to upregulation of miR-16, miR-15, miR-23, miR-19, miR-125, and downregulation of let-7, miR-194, miR-373, miR-124, miR-146, miR-369, and miR-652. These alterations alter cell cycle, oxidative stress, inflammation, oncogene suppression, and malignant transformation. Also DNA methylation is altered as a consequence of miR-29 modification induced by radon. Indeed miR-29 targets DNA methyltransferases causing inhibition of CpG sites methylation. Massive microRNA dysregulation occurs in the lung due to radon expose and is functionally related with the resulting lung damage. However, in humans this massive lung microRNA alterations only barely reflect onto blood microRNAs. Indeed, blood miR-19 was not found altered in radon-exposed subjects. Thus, microRNAs are massively dysregulated in experimental models of radon lung carcinogenesis. In humans these events are initially adaptive being aimed at inhibiting neoplastic transformation. Only in case of long-term exposure to radon, microRNA alterations lead towards cancer development. Accordingly, it is difficult in human to establish a microRNA signature reflecting radon exposure. Additional studies are required to understand the role of microRNAs in pathogenesis of radon-induced lung cancer.

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  • miR-23a can be upregulated in human bronchial epithelial cells induced by radon exposure, leading to changes in cell cycle, oxidative stress, inflammation, oncogene suppression, and malignant transformation.

    “miR-23a can also be upregulated in human bronchial epithelial cells induced by radon exposure, leading to changes in cell cycle, oxidative stress, inflammation, oncogene suppression, and malignant transformation.”

    From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [90]

    The Abstract (page not provided) attributes changes in cell cycle, oxidative stress, inflammation, oncogene suppression, and malignant transformation to radon-associated microRNA alterations collectively, not to miR-23a specifically. Section 7 (page not provided) reports upregulation of miR-23b-3p—not miR-23a—in radon-exposed human bronchial epithelial cells. The claimed miR-23a identity and its specific causal role are therefore unsupported. (LLM, conf=0.88)

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Authors
Bersimbaev, R., Pulliero, A., Bulgakova, O., Kussainova, A., Aripova, A., & Izzotti, A.
Affiliations
  • L. N. Gumilyov Eurasian National University (KZ)
  • University of Genoa (IT)
  • Department of General Biology and Genomics, Institute of Cell Biology and Biotechnology, L.N.Gumilyov Eurasian National University, Nur-Sultan, Akmola 010008, Kazakhstan
  • Ospedale Policlinico San Martino (IT)
Corresponding author
Pulliero, Alessandra
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2020-03-20
Volume
21
Issue
6
Pages
2154
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms21062154
PMC
PMC7139524
OpenAlex
W3011521636
Cited by
53
References
100
Citations by year
2026: 6 · 2025: 5 · 2024: 11 · 2023: 8 · 2022: 13 · 2021: 6 · 2020: 4
FWCI
0.79
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion, other-oa)
Funders
Associazione Italiana per la Ricerca sul Cancro (IG-2017 - 20699)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Health Sciences › Health Professions › Radiological and Ultrasound Technology › Radioactivity and Radon Measurements
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Keywords
radon, lung cancer, microRNA, biomonitoring, non-smoker lung cancer, bronchial epithelium, miR-19, DNA methylation, miR-29, DNA methyltransferases, CpG methylation, oxidative stress, inflammation, cell cycle, blood microRNA, radon exposure
MeSH terms
Radiation Exposure, Biological Monitoring, Animals, Humans, Lung Neoplasms, Radon, MicroRNAs, Epigenesis, Genetic

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