STAT1 Is Required for Decreasing Accumulation of Granulocytic Cells via IL-17 during Initial Steps of Colitis-Associated Cancer

Delgado-Ramirez, Yael; Baltazar-Perez, Itzel; Martinez, Yamileth; Callejas, Blanca E.; Medina-Andrade, Itzel; Olguín, Jonadab E.; Delgado-Buenrostro, Norma L.; Chirino, Yolanda I.; Terrazas, Luis I.; Leon-Cabrera, Sonia

doi:10.3390/ijms22147695

STAT1 Is Required for Decreasing Accumulation of Granulocytic Cells via IL-17 during Initial Steps of Colitis-Associated Cancer

Signal transducer and activator of transcription 1 (STAT1) acts as a tumor suppressor molecule in colitis-associated colorectal cancer (CAC), particularly during the very early stages, modulating immune responses and controlling mechanisms such as apoptosis and cell proliferation. Previously, usi…