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The DOI matches its Crossref record; 95 of the 95 references it cites were found in a registry or an index.

The Flavonoid Biosynthesis Network in Plants

Open access
Liu, Weixin, Feng, Yi, Yu, Suhang, Fan, Zhengqi, Li, Xinlei, Li, Jiyuan, Yin, Hengfu·2021·International Journal of Molecular Sciences

Abstract

Flavonoids are an important class of secondary metabolites widely found in plants, contributing to plant growth and development and having prominent applications in food and medicine. The biosynthesis of flavonoids has long been the focus of intense research in plant biology. Flavonoids are derived from the phenylpropanoid metabolic pathway, and have a basic structure that comprises a C15 benzene ring structure of C6-C3-C6. Over recent decades, a considerable number of studies have been directed at elucidating the mechanisms involved in flavonoid biosynthesis in plants. In this review, we systematically summarize the flavonoid biosynthetic pathway. We further assemble an exhaustive map of flavonoid biosynthesis in plants comprising eight branches (stilbene, aurone, flavone, isoflavone, flavonol, phlobaphene, proanthocyanidin, and anthocyanin biosynthesis) and four important intermediate metabolites (chalcone, flavanone, dihydroflavonol, and leucoanthocyanidin). This review affords a comprehensive overview of the current knowledge regarding flavonoid biosynthesis, and provides the theoretical basis for further elucidating the pathways involved in the biosynthesis of flavonoids, which will aid in better understanding their functions and potential uses.

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Metadata

Authors
Liu, W., Feng, Y., Yu, S., Fan, Z., Li, X., Li, J., & Yin, H.
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2021-11-26
Volume
22
Issue
23
Pages
12824
ISSN
1422-0067 (ISSN-L)
OpenAlex
W3216174003
Cited by
1,020
References
95
FWCI
32.94
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: The Flavonoid Biosynthesis Network in Plants. https://app.cochat.ai/papers/10.3390/ijms222312824
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Liu, W., Feng, Y., Yu, S., Fan, Z., Li, X., Li, J., & Yin, H. (2021). The Flavonoid Biosynthesis Network in Plants. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms222312824

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