Psoriasis and Systemic Inflammatory Disorders
Open accessAbstract
Psoriasis is a representative inflammatory skin disease occupied by large surface involvement. As inflammatory cells and cytokines can systemically circulate in various organs, it has been speculated that psoriatic skin inflammation influences the systemic dysfunction of various organs. Recent updates of clinical studies and experimental studies showed the important interaction of psoriasis to systemic inflammatory diseases. Furthermore, the importance of systemic therapy in severe psoriasis is also highlighted to prevent the development of systemic inflammatory diseases. In this review, we introduced representative systemic inflammatory diseases associated with psoriasis and the detailed molecular mechanisms.
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Psoriasis is a systemic inflammatory condition associated with comorbidities such as cardiometabolic disease.
“Psoriasis is increasingly recognized as a systemic inflammatory condition associated with comorbidities such as cardiometabolic disease, which has influenced treatment goals toward achieving sustained disease control and potentially modifying long-term inflammatory burden [34,35].”
From The Cutaneous Immune Microenvironment in Selected Inflammatory Skin Diseases: Linking Histopathology, Mechanisms, and Targeted Therapy (2026) · cites this paper as [34]
Aryl hydrocarbon receptor modulators such as tapinarof influence keratinocyte differentiation, oxidative stress, and inflammatory gene expression, representing a non-immunosuppressive approach that targets both epithelial and immune components of psoriasis.
“For example, aryl hydrocarbon receptor modulators such as tapinarof influence keratinocyte differentiation, oxidative stress, and inflammatory gene expression, representing a non-immunosuppressive approach that targets both epithelial and immune components of the disease [33,34].”
From The Cutaneous Immune Microenvironment in Selected Inflammatory Skin Diseases: Linking Histopathology, Mechanisms, and Targeted Therapy (2026) · cites this paper as [34]
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References 125 · Cited by 104
Research works printed but not linked: 1
- [108]Duplechain A. Conrady C.D. Patel B.C. Baker S. Uveitis StatPearls StatPearls Publishing Treasure Island, FL, USA 2022 31082037
- Authors
- Tashiro, T., & Sawada, Y.
- Affiliations
- University of Occupational and Environmental Health Japan (JP)
- Corresponding author
- Sawada, Yu
- ORCID
- Sawada, Yu
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2022-04-18
- Volume
- 23
- Issue
- 8
- Pages
- 4457
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC9028262
- OpenAlex
- W4224231443
- Cited by
- 104
- References
- 125
- Citations by year
- 2026: 22 · 2025: 28 · 2024: 25 · 2023: 25 · 2022: 4
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Rheumatology › Spondyloarthritis Studies and Treatments
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- psoriasis, systemic inflammatory disease, cytokines, inflammatory cells, systemic inflammation, molecular mechanisms, systemic therapy, severe psoriasis
- MeSH terms
- Humans, Inflammation, Psoriasis, Skin, Cytokines
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