The role of adipokines in inflammatory mechanisms of obesity
Open accessAbstract
Adipokines are currently widely studied cellular signaling proteins produced by adipose tissue and involved in various processes, including inflammation; energy and appetite modulation; lipid and glucose metabolism; insulin sensitivity; endothelial cell functioning; angiogenesis; the regulation of blood pressure; and hemostasis. The current review attempted to highlight the key functions of adipokines in the inflammatory mechanisms of obesity, its complications, and its associated diseases. An extensive search for materials on the role of adipokines in the pathogenesis of obesity was conducted online using the PubMed and Scopus databases until October 2022.
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Several molecules secreted by adipose tissue correlate directly with adipose tissue mass and can act as biological markers of inflammation and metabolic dysfunction.
“These include several molecules that correlate directly with adipose tissue mass and can act as biological markers of inflammation and metabolic dysfunction [[32], [33], [34], [35]].”
From Antibody blockade of activin type II receptors preserves skeletal muscle mass and enhances fat loss during GLP-1 receptor agonism (2024) · cites this paper as [33]
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References 162 · Cited by 289
- Authors
- Kirichenko, T. V., Markina, Y. V., Bogatyreva, A. I., Tolstik, T. V., Varaeva, Y. R., & Starodubova, A. V.
- Affiliations
- National Medical Research Center of Cardiology (RU)
- Russian Scientific Center of Surgery (RU)
- Federal Research Centre of Nutrition and Biotechnology (RU)
- Corresponding author
- Markina, Yuliya V.
- ORCID
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2022-11-29
- Volume
- 23
- Issue
- 23
- Pages
- 14982
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC9740598
- OpenAlex
- W4310999169
- Cited by
- 289
- References
- 162
- Citations by year
- 2026: 86 · 2025: 107 · 2024: 80 · 2023: 15 · 2022: 1
- FWCI
- 8.04
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Russian Science Foundation (22-15-00252)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- adipokines, obesity, inflammation, adipose tissue, insulin sensitivity, energy homeostasis, appetite regulation, lipid metabolism, glucose metabolism, endothelial function, angiogenesis, blood pressure regulation, hemostasis, obesity-related comorbidities
- MeSH terms
- Adipose Tissue, Humans, Inflammation, Insulin Resistance, Obesity, Adipokines
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