Why Is Longevity Still a Scientific Mystery? Sirtuins—Past, Present and Future
Open accessAbstract
The sirtuin system consists of seven highly conserved regulatory enzymes responsible for metabolism, antioxidant protection, and cell cycle regulation. The great interest in sirtuins is associated with the potential impact on life extension. This article summarizes the latest research on the activity of sirtuins and their role in the aging process. The effects of compounds that modulate the activity of sirtuins were discussed, and in numerous studies, their effectiveness was demonstrated. Attention was paid to the role of a caloric restriction and the risks associated with the influence of careless sirtuin modulation on the organism. It has been shown that low modulators’ bioavailability/retention time is a crucial problem for optimal regulation of the studied pathways. Therefore, a detailed understanding of the modulator structure and potential reactivity with sirtuins in silico studies should precede in vitro and in vivo experiments. The latest achievements in nanobiotechnology make it possible to create promising molecules, but many of them remain in the sphere of plans and concepts. It seems that solving the mystery of longevity will have to wait for new scientific discoveries.
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Caloric restriction modulates mitochondrial activity and suppresses oxidative damage through sirtuin regulation and catalysis.
“It has been documented that caloric restriction modulates mitochondrial activity and suppressed oxidative damage through the sirtuin regulation and catalysis.”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Zietara et al. 2023
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References 290 · Cited by 40
- Authors
- Ziętara, P., Dziewięcka, M., & Augustyniak, M.
- Affiliations
- University of Silesia in Katowice (PL)
- Corresponding author
- Augustyniak, Maria
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2022-12-31
- Volume
- 24
- Issue
- 1
- Pages
- 728
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC9821238
- OpenAlex
- W4313471895
- Cited by
- 40
- References
- 290
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 16 · 2023: 7
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Research Excellence Initiative of the University of Silesia in Katowice
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Keywords
- sirtuins, aging, longevity, lifespan extension, caloric restriction, bioavailability, nanobiotechnology, antioxidant defense, cell cycle regulation, metabolism
- MeSH terms
- Antioxidants, Longevity, Caloric Restriction, Sirtuins
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