Apoe4 and Alzheimer’s Disease Pathogenesis—Mitochondrial Deregulation and Targeted Therapeutic Strategies

Cited by (157)

Items 101–157 of 157

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2. The mitochondria-synapse axis in Alzheimer’s disease: Lost coordination in early stages
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4. Alone in the Mind: Review of Research Examining the Link Between Loneliness and Dementia
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5. Elevated blood glucose levels are associated with the progression of brain hypometabolism, and HDL-C and APOE4 add to this association
   Aravind Lathika Rajendrakumar, Svetlana V. Ukraintseva, Olivia Bagley, Matt Duan, Anatoliy I. Yashin, Konstantin G. Arbeev, the Alzheimer’s Disease Neuroimaging Initiative · 2024 · medRxiv
6. Sister haplotypes and recombination disequilibrium: A new Approach to identify associations of haplotypes with complicated diseases
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7. Basic Experimental Model of Memory Impairment in Alzheimer’s Disease
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8. Status of current research into cognitive impairment in human immunodeficiency virus based on magnetic resonance imaging and apolipoprotein E4 interaction mechanism
   Zhongkai Zhou, Ying Shi, Wei Wang · 2023 · Radiology of Infectious Diseases
9. Sister haplotypes and recombination disequilibrium: a new approach to identify associations of haplotypes with complex diseases
   Shun-Yao Liao, Yuan-De Tan · 2024 · Frontiers in Genetics
10. APOLIPOPROTEIN E GENE POLYMORPHISMS AND PLASMA LIPIDS IN PERSONS LIVING WITH HIV: A CROSS SECTIONAL STUDY.
    Modupe Akinrele Kuti, Olabisi Titilayo BAMIDELE, N S Nduka, O Olaniyi, Olajumoke Ajele Ogundeji, K S Adedapo, Olutosin Alaba Awolude · 2024 · PubMed Central
11. Alzheimer Hastalığında ApoE4 Varyantı ve Beslenmedeki Rolü
    Merve Saruhan · 2024 · Türkiye Sağlık Bilimleri ve Araştırmaları Dergisi
12. Alzheimer’s Disease and Diabetes Mellitus: Molecular Links
    Dildar Konukoğlu · 2024
13. Charnolosome nanotheranostics in Alzheimer disease and other taupathies
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14. Genetic association of ABCA7 and PSEN1 polymorphisms with Alzheimer’s disease in the northeast Algerian population: Exploring risk factors
    Rayene Achou, Ouarda Sariyah Ayachi, Yasmina Boukhenaf, Rania Laouar, Gharzouli Razika, M’zahem Abderrahim, Houda Boulala, Noureddine Abadi, Dalila Satta · 2025 · Archives of Biological Sciences
15. Potential multiple disease progression pathways in female patients with Alzheimer’s disease inferred from transcriptome and epigenome data of the dorsolateral prefrontal cortex
    Kousei Honda, Akinori Awazu · 2025 · PLoS ONE
16. Mitochondrial Dysfunction in Alzheimer’s Disease: A Comprehensive Review of Synaptopathy Mechanisms
    Sehyoun Yoon · 2025 · IntechOpen eBooks
17. Prospective Assessment of Alzheimer's Disease-Like Hypometabolism Pattern in the Brain of Diabetics in Contrast to Non-diabetics on Positron Emission Tomography-Computed Tomography Images Using Fluorodeoxyglucose in India
    Pankaj Kumar, Vikram Ramchandra Lele, Md. Jawed Akhtar · 2025 · Cureus
18. A Narrative Review on APOE in Breast Cancer: From Prognosis to Cognitive Decline
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19. The protective PLCG2 variants delay Alzheimer's disease onset age in APOE ϵ4 carriers
    H. Jeskanen, S. Heikkinen, I. Kervinen, J. Lehtisalo, T. Ngandu, R.-M. Willman, J. Rosa, D. Hoffmann, FinnGen, V. Leinonen et al. · 2025 · medRxiv
20. The association of human apolipoprotein ε4 with dementia, cognition, imaging, and plasma biomarkers of neurodegeneration in a sample of older adults in the Democratic Republic of the Congo
    Jean N. Ikanga, Saranya Sundaram Patel, Megan Schwinne, Caterina Obenauf, Emmanuel Epenge, Guy Gikelekele, Nathan Tshengele, Immaculée Kavugho, Samuel Ma Miezi Mampunza, Lelo Mananga et al. · 2025 · Alzheimer s & Dementia
21. Association of APOE ε4 with cerebrospinal fluid protein and amyloid-β 42 levels in Alzheimer's disease
    Renyu Chen, Fang Yuan, Shuai Liu, Hao Wu, Zhihong Shi, Cihan Di, Shiyu Fan, Bing Liang, Yong Ji · 2025 · Journal of Alzheimer s Disease Reports
22. Harnessing team science in dementia research: Insights from the Alzheimer's disease research group in South Carolina
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23. Antibodies targeting amyloid-β and Tau oligomers in Alzheimer’s disease
    Subashchandrabose Chinnathambi, Nagaraj Rangappa, Madhura Chandrashekar · 2025 · Advances in protein chemistry and structural biology
24. Use of rodent models in drug discovery for Alzheimer’s disease
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25. Neurodegenerative disorders: Why do we need new therapies?
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26. Alzheimer-related individual factors modulate effects of transcranial direct current stimulation strength on white matter integrity in mild cognitive impairment
    Jung‐Won Lee, Sung‐Hwan Kim, Suhyung Kim, Yoo Hyun Um, Sheng‐Min Wang, TaeYeong Kim, Donghyeon Kim, Hyun Kook Lim, Chang Uk Lee, Dong Woo Kang · 2025 · Scientific Reports
27. Apolipoprotein E genotypes are associated with diabetic peripheral neuropathy in Lebanese adults with type 2 diabetes: a case-control study
    Rita Nemr, Sabrina Zidi, Akram Salim Echtay, Eddie Racoubian, Nisrine Beydoun, Wassim Youssef Almawi · 2025 · Frontiers in Endocrinology
28. Relationship between amyloid burden, cholinergic integrity, and cognitive function
    Li‐Hua Lee, Chia‐Ju Chou, Yao‐Chia Shih, Yu-Ming Fang, Yen-Lin Chiu, Yi‐Fang Chuang, Yi-Chien Liu · 2025 · Journal of Alzheimer s Disease
29. A dive into the untapped potential of marine compounds in counteracting neurodegeneration
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30. ALDH2 activation protects against mutant TOMM40-mediated mitochondrial dysfunction and neurodegeneration in Alzheimer's disease
    Yi-Chun Chen, Tai-Ju Chiu, Yah-Yuan Wu, Yu-Ting Wang, Kuan-Hsuan Wu, Tu‐Hsueh Yeh, Ya‐Ju Hsieh, Wan-Shia Chen, Ching‐Chi Chiu · 2026 · Life Sciences
31. APOE, Gene Senescence, and Genotoxicity
    Letícia Rodrigues Sampaio, Ronald Feitosa Pinheiro · 2025 · Springer eBooks
32. Serum Expression of miR-106b-3p and Its Diagnostic Significance in Alzheimer Disease
    Dan Hou, Zhiyong Hou, Hong Qu, Ming Yang Sun, Liping Wang · 2026 · Alzheimer Disease & Associated Disorders
33. APOE4 Alters Early Transcriptional Programs and Inflammatory Signaling in Human Induced Pluripotent Stem Cells
    Wiebke Schulten, Nele Johanne Czaniera, Mehran Fazel, Barbara Kaltschmidt, Christian Kaltschmidt · 2026 · International Journal of Molecular Sciences
34. Quantitative structure–activity relationship (QSAR) investigation of isonicotinamide derivatives as GSK-3β inhibitors using DFT based quantum descriptors for Alzheimer’s disease
    Sarthak J. Trivedi, Sutapa Mondal Roy, Debesh Ranjan Roy · 2026 · Interactions
35. APOE, Gene Senescence, and Genotoxicity
    Letícia Rodrigues Sampaio, Ronald Feitosa Pinheiro · 2026 · Springer eBooks
36. Apolipoprotein E (APOE) in Alzheimer’s Disease: Mechanisms, Modifiers, and Therapeutic Implications
    Shafee Ur Rehman · 2026 · Bengal Journal of Psychiatry
37. TabTransformer-based Model for Alzheimer’s Disease Classification using EHR and Cohort-based Clinical Data
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38. Mitophagy deficiency and calcium dyshomeostasis underlying the pathogenesis and progression of Alzheimer's disease
    Guangrong Meng, Liang Cai, Zhongcheng Mo, Shaoying An, Wenhui Sun, Ping Shen, Yuanjie Xie · 2026 · Journal of Alzheimer s Disease
39. Therapeutic Gene Editing of APOE4 in Sporadic Alzheimer's Disease via Prime Editor 7
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40. Oxidative Stress in Alzheimer’s Disease: Can Dietary Interventions Provide Neuroprotection?
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41. A score based on MRI imaging variables can predict time to moderate progression in mild cognitive impairment: Multimodal data integration study
    Elżbieta Jodłowska-Siewert, Limeng Liu, Kaifeng Yang, Denis Ostroushko, Pamela L. Lutsey, Thierry Chekouo, Sandra E. Safo, Alzheimer’s Disease Neuroimaging Initiative · 2026 · Journal of Alzheimer s Disease
42. Adeno-Associated Virus-Mediated Central Nervous System Gene Transfer to Suppress Alzheimer’s Disease High-Risk APOE4 Variant and Replace with Protective APOE2
    Kalpita R. Karan, Neil R. Hackett, Ronald G. Crystal · 2026 · Human Gene Therapy
43. Harnessing autophagy and its transcriptional regulation in tumorigenesis and neurodegeneration: Potential and existing therapeutic strategies
    Parul Suri, Abel B. Daartey, D M Isha Olive Khan, Naga Pradeep Rayana, Rameswari Chilamakuri, Deepika Godugu, Mahan Gholam Azad, Katelyn Louise Reeb, Des Raymond Richardson · 2026 · Pharmacological Reviews
44. Beyond Targeted Gene Panels: Whole-Exome Sequencing as a Strategic Platform for Precision Therapeutics in Alzheimer’s Disease
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45. Artemether alleviates Aβ1–42-induced neuronal cell damage via PGC-1α-mediated mitochondrial homeostasis in Alzheimer's disease
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46. Exploratory associations between APOE-ε4 carrier status and facial neuromuscular activity in cognitively intact adults: a cross-sectional surface electromyography study
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47. Platelet count polygenic scores may modify the effect of aspirin in primary prevention of dementia
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48. Intermittent fasting as a therapeutic strategy in Alzheimer’s disease: Understanding of brain-derived neurotrophic factor modulation
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49. Peptides and Lysine as Emerging Therapies for Alzheimer’s Disease: A Systematic Review
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50. The ferroptosis-lipid metabolism-neuroinflammation axis in Alzheimer's disease: A review of mechanistic interplay and therapeutic implications
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51. Epigenetic mechanisms in brain development and in neurodegeneration
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52. Exploring the role of depression in the association between APOE ε4 and cognitive function: Evidence from the Brain Health Registry
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53. Real-world safety and efficacy of lecanemab in the treatment of Alzheimer’s disease: a systematic review and meta-analysis
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54. Association of ApoE Gene Polymorphisms With Circulating Biomarkers, Oxidative Stress, and Physiological Markers in Early- and Late-onset Depression in Older Adults: A Case-control Study
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55. A phase III trial of ALZT-OP1 (cromolyn + ibuprofen) in early Alzheimer's disease: Primary results and exploratory analyses by APOE4 genotype
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56. Dihydrocaffeic acid alleviates APOE4-associated astrocyte dysfunction and cognitive impairment via LRP1/p38 MAPK signaling
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57. Therapeutic potential of targeting immune-metabolic pathways and lifestyle interventions on immunometabolism and neurodegeneration
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