Worth a Double Take? An In-Depth Review of Lung Retransplantation
Open accessAbstract
Provided advancements in Lung Transplantation (LT) survival, the efficacy of Lung Retransplantation (LRT) has often been debated. Decades of retrospective analyses on thousands of LRT cases provide insight enabling predictive patient criteria for retransplantation. This review used the Preferred Reporting Items for Systematic Reviews and Meta Analyses (PRISMA) guidelines. The PubMed search engine was utilized for articles relating to LRT published through August 2023, and a systematic review was performed using Covidence software version 2.0 (Veritas Health Innovation, Australia). Careful patient selection is vital for successful LRT, and the benefit leans in favor of those in optimal health following their initial transplant. However, the lack of a standardized approach remains apparent. Through an in-depth review, we will address considerations such as chronic lung allograft dysfunction, timing to LRT, surgical and perioperative complexity, and critical ethical concerns that guide the current practice as it relates to this subset of patients for whom LRT is the only therapeutic option available.
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ReTx accounted for only 3.9% of our total volume, which was lower than the 4-16% reported in previous single-center studies and the 4-6% reported in the ISHLT registry between 2005 and 2017.
“Despite performing over 1000 lung transplants during the 18-year study period, ReTx accounted for only 3.9% of our total volume, which was lower than the 4–16% reported in previous single-center studies across the U.S., North America, and Europe,3, 6, 7, 8, 9 and the 4–6% reported in the ISHLT registry between 2005 and 2017.5”
From Lung retransplantation during the Lung Allocation Score era: Outcomes from a large single center (2026) · cites this paper as [9]
The Introduction says lung retransplantation accounts for about 5% of lung transplants globally. The Discussion reports ISHLT figures of 5.1% for single and 3.4% for bilateral transplants in a period ending in 2013, and separately describes an ISHLT cohort from 2005–2017. It does not give a 4–6% ISHLT rate for 2005–2017. The citing paper’s own 3.9% volume and its single-center comparison are not attributed to this source. (LLM, conf=0.86)
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References 51 · Cited by 4
- Authors
- Dawodu, G., Gulati, S., Bugacov, H., Laskey, D., Housman, B., Seethamraju, H., & Scheinin, S.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Dawodu, Gbalekan
- Venue
- Journal of Clinical Medicine
- Publisher
- MDPI AG
- Published
- 2023-11-30
- Volume
- 12
- Issue
- 23
- Pages
- 7418
- ISSN
- 2077-0383 (ISSN-L)
- PMC
- PMC10706877
- OpenAlex
- W4389203647
- Cited by
- 4
- References
- 51
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1
- FWCI
- 0.26
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Clinical Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Organ Donation and Transplantation
- Keywords
- lung retransplantation, lung transplantation, chronic lung allograft dysfunction, patient selection, transplant ethics, transplant outcomes
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