Molecular Mechanisms of 5-Fluorocytosine Resistance in Yeasts and Filamentous Fungi
Open accessAbstract
Effective management and treatment of fungal diseases is hampered by poor diagnosis, limited options for antifungal therapy, and the emergence of antifungal drug resistance. An understanding of molecular mechanisms contributing to resistance is essential to optimize the efficacy of currently available antifungals. In this perspective, one of the oldest antifungals, 5-fluorocytosine (5-FC), has been the focus of recent studies applying advanced genomic and transcriptomic techniques to decipher the order of events at the molecular level that lead to resistance. These studies have highlighted the complexity of resistance and provided new insights that are reviewed in the present paper.
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References 81 · Cited by 96
Research works printed but not linked: 1
- [14]World Health Organization Guidelines for the Diagnosis, Prevention, and Management of Cryptococcal Disease in HIV-Infected Adults, Adolescents and Children, March 2018: Supplement to the 2016 Consolidated Guidelines of the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection WHO Geneva, Switzerland 2018 30285342
- Authors
- Delma, F. Z., Al-Hatmi, A. M. S., Brüggemann, R. J. M., Melchers, W. J. G., de Hoog, S., Verweij, P. E., & Buil, J. B.
- Affiliations
- Radboud University Medical Center (NL)
- Natural & Medical Sciences Research Center, University of Nizwa, Nizwa 616, Oman
- Centre of Expertise in Mycology Radboudumc/CWZ, Radboudumc Center for Infectious Diseases (RCI), 6252 AG Nijmegen, The Netherlands
- Corresponding author
- Buil, Jochem B.
- ORCID
- Venue
- Journal of Fungi
- Publisher
- MDPI AG
- Published
- 2021-10-27
- Volume
- 7
- Issue
- 11
- Pages
- 909
- ISSN
- 2309-608X (ISSN-L)
- PMC
- PMC8623157
- OpenAlex
- W3209934681
- Cited by
- 96
- References
- 81
- Citations by year
- 2026: 21 · 2025: 27 · 2024: 20 · 2023: 19 · 2022: 9
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Fungi (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Radboud Repository (Radboud University) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
- Keywords
- 5-fluorocytosine, antifungal resistance, molecular mechanisms of resistance, yeast, filamentous fungi, antifungal therapy, fungal diseases, transcriptomics
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