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Bioinformatic Analysis of Secondary Metabolite Biosynthetic Potential in Pathogenic Fusarium
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Abstract
Fusarium species are among the filamentous fungi with the most pronounced impact on agricultural production and human health. The mycotoxins produced by pathogenic Fusarium not only attack various plants including crops, causing various plant diseases that lead to reduced yields and even death, but also penetrate into the food chain of humans and animals to cause food poisoning and consequent health hazards. Although sporadic studies have revealed some of the biosynthetic pathways of Fusarium toxins, they are insufficient to satisfy the need for a comprehensive understanding of Fusarium toxin production. In this study, we focused on 35 serious pathogenic Fusarium species with available genomes and systematically analyzed the ubiquity of the distribution of identified Fusarium- and non-Fusarium-derived fungal toxin biosynthesis gene clusters (BGCs) in these species through the mining of core genes and the comparative analysis of corresponding BGCs. Additionally, novel sesterterpene synthases and PKS_NRPS clusters were discovered and analyzed. This work is the first to systematically analyze the distribution of related mycotoxin biosynthesis in pathogenic Fusarium species. These findings enhance the knowledge of mycotoxin production and provide a theoretical grounding for the prevention of fungal toxin production using biotechnological approaches.
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Fuertes, P. R., Søndergaard, T. E., Sandmann, M., Wollenberg, R. D., Nielsen, K. F., Hansen, F. T., Giese, H., Brodersen, D. E., & Sørensen, J. L. (2016) · Current Genetics · doi:10.1007/s00294-016-0584-4 · Cited by 28
Biosynthesis of Fusapyrone Depends on the H3K9 Methyltransferase, FmKmt1, in Fusarium mangiferae
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Biosynthesis of the Fusarium Mycotoxin (−)-Sambutoxin
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Bansal, Y., Singla, N., Kaistha, N., Sood, S., & Chander, J. (2019) · Current Medical Mycology · doi:10.18502/cmm.5.4.2149 · Cited by 22
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Liu, S., Wu, B. M., Shu-xia, L., Shen, Z., Li, R., Yi, G., Li, C., & Guo, X. (2019) · Frontiers in Plant Science · doi:10.3389/fpls.2019.01069 · Cited by 19
Westphal, K. R., Bachleitner, S., Severinsen, M. M., Brundtø, M. L., Hansen, F. T., Sørensen, T., Wollenberg, R. D., Lysøe, E., Studt, L., Sørensen, J. L., et al. (2021) · Journal of Natural Products · doi:10.1021/acs.jnatprod.0c00947 · Cited by 19
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A Fungal N ‐Dimethylallyltryptophan Metabolite from Fusarium fujikuroi
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Metadata
- Authors
- Lin, C., Feng, X.-L., Liu, Y., Li, Z.-C., Li, X.-Z., & Qi, J.
- Affiliations
- Northwest A&F University (CN)
- Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Xianyang 712100, China
- State Key Laboratory of Plateau Ecology and Agriculture, Qinghai Academy of Animal and Veterinary Sciences, Qinghai University, Xining 810016, China
- Corresponding author
- Qi, Jianzhao
- Venue
- Journal of Fungi
- Publisher
- MDPI AG
- Published
- 2023-08-15
- Volume
- 9
- Issue
- 8
- Pages
- 850
- ISSN
- 2309-608X (ISSN-L)
- PMC
- PMC10455296
- OpenAlex
- W4385840277
- Cited by
- 32
- References
- 110
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 6 · 2023: 2
- FWCI
- 4.98
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Fungi (publishedVersion, cc-by)
- Preprints.org (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Key R&D Projects in Shaanxi Province of China (2023-YBSF-164)
- Topics
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Mycotoxins in Agriculture and Food
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Pathogens and Fungal Diseases
- Keywords
- Fusarium, mycotoxin biosynthesis, biosynthetic gene clusters, secondary metabolites, fungal toxin production, comparative genomics, plant pathogens, food poisoning
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.