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Cited by 64Spaceflight effects on biologyBacterial Genetics and BiotechnologySpace Science and Extraterrestrial Life

The Impacts of Microgravity on Bacterial Metabolism

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Sharma, Gayatri, Curtis, Patrick D.·2022·Life
DOI 10.3390/life12060774PMC PMC9225508
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Abstract

The inside of a space-faring vehicle provides a set of conditions unlike anything experienced by bacteria on Earth. The low-shear, diffusion-limited microenvironment with accompanying high levels of ionizing radiation create high stress in bacterial cells, and results in many physiological adaptations. This review gives an overview of the effect spaceflight in general, and real or simulated microgravity in particular, has on primary and secondary metabolism. Some broad trends in primary metabolic responses can be identified. These include increases in carbohydrate metabolism, changes in carbon substrate utilization range, and changes in amino acid metabolism that reflect increased oxidative stress. However, another important trend is that there is no universal bacterial response to microgravity, as different bacteria often have contradictory responses to the same stress. This is exemplified in many of the observed secondary metabolite responses where secondary metabolites may have increased, decreased, or unchanged production in microgravity. Different secondary metabolites in the same organism can even show drastically different production responses. Microgravity can also impact the production profile and localization of secondary metabolites. The inconsistency of bacterial responses to real or simulated microgravity underscores the importance of further research in this area to better understand how microbes can impact the people and systems aboard spacecraft.

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  • There are no universal responses to the altered gravity environment.

    “there are no universal responses to the altered gravity environment (Sharma & Curtis, 2022).”

    From Simple and effective remediation strategies of Martian perchlorates (2026) · cites this paper as Sharma & Curtis, 2022

    The Abstract (page not provided) says there is no universal bacterial response to microgravity: different bacteria can respond differently to the same stress. The citing sentence omits the bacterial scope and states the point more broadly for responses to altered gravity. (LLM, conf=0.84)

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Cited by

Sorted by citations

Authors
Sharma, G., & Curtis, P. D.
Affiliations
University of Mississippi (US)
Corresponding author
Curtis, Patrick D.
ORCID
Venue
Life
Publisher
MDPI AG
Published
2022-05-24
Volume
12
Issue
6
Pages
774
ISSN
2075-1729 (ISSN-L)
DOI
10.3390/life12060774
PMC
PMC9225508
OpenAlex
W4281483800
Cited by
64
References
2
Citations by year
2026: 19 · 2025: 14 · 2024: 13 · 2023: 13 · 2022: 5
FWCI
1.55
Type
journal article
Language
en
Open access
Licence
Locations
  • Life (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
NASA EPSCoR (80NSSC19M0013)
Topics
  • Health Sciences › Medicine › Physiology › Spaceflight effects on biology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
  • Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Space Science and Extraterrestrial Life
Keywords
microgravity, bacterial metabolism, spaceflight, simulated microgravity, primary metabolism, secondary metabolites, carbohydrate metabolism, carbon substrate utilization, amino acid metabolism, oxidative stress, ionizing radiation, microbial stress response, spacecraft microbiology

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