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Cited by 55Bone Tissue Engineering Materialsbiodegradable polymer synthesis and properties3D Printing in Biomedical Research

The State of Starch/Hydroxyapatite Composite Scaffold in Bone Tissue Engineering with Consideration for Dielectric Measurement as an Alternative Characterization Technique

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Mohd Roslan, Mohd Riza, Mohd Kamal, Nadhiya Liyana, Abdul Khalid, Muhammad Farid, Mohd Nasir, Nashrul Fazli, Cheng, Ee Meng, Beh, Chong You, Tan, Joo Shun, Mohamed, Mohd Shamzi·2021·Materials
DOI 10.3390/ma14081960PMC PMC8070798
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Abstract

Hydroxyapatite (HA) has been widely used as a scaffold in tissue engineering. HA possesses high mechanical stress and exhibits particularly excellent biocompatibility owing to its similarity to natural bone. Nonetheless, this ceramic scaffold has limited applications due to its apparent brittleness. Therefore, this had presented some difficulties when shaping implants out of HA and for sustaining a high mechanical load. Fortunately, these drawbacks can be improved by combining HA with other biomaterials. Starch was heavily considered for biomedical device applications in favor of its low cost, wide availability, and biocompatibility properties that complement HA. This review provides an insight into starch/HA composites used in the fabrication of bone tissue scaffolds and numerous factors that influence the scaffold properties. Moreover, an alternative characterization of scaffolds via dielectric and free space measurement as a potential contactless and nondestructive measurement method is also highlighted.

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  • When combined with hydroxyapatite in bone tissue repair, the scaffold's improved structural and biological functions were described.

    “When combined with hydroxyapatite in the context of bone tissue repair, the scaffold’s improved structural and biological functions were described [76].”

    From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [76]

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Sorted by citations

Authors
Mohd Roslan, M. R., Mohd Kamal, N. L., Abdul Khalid, M. F., Mohd Nasir, N. F., Cheng, E. M., Beh, C. Y., Tan, J. S., & Mohamed, M. S.
Affiliations
  • Biomedical Electronic Engineering Program, School of Mechatronic Engineering, Universiti Malaysia Perlis, Arau 02600, Perlis, Malaysia
  • Malaysian Institute of Aviation Technology, Universiti Kuala Lumpur, Dengkil 43800, Selangor, Malaysia
  • Faculty of Electrical Engineering, Microwave Research Institute (MRI), Universiti Teknologi MARA (UiTM), Shah Alam 40450, Selangor, Malaysia
  • Universiti Malaysia Perlis (MY)
  • Universiti Putra Malaysia (MY)
Corresponding author
Mohamed, Mohd Shamzi
ORCID
Venue
Materials
Publisher
MDPI AG
Published
2021-04-14
Volume
14
Issue
8
Pages
1960
ISSN
1996-1944 (ISSN-L)
DOI
10.3390/ma14081960
PMC
PMC8070798
OpenAlex
W3154811060
Cited by
55
References
0
Citations by year
2026: 4 · 2025: 12 · 2024: 14 · 2023: 14 · 2022: 6 · 2021: 5
FWCI
0.82
Type
journal article
Language
en
Open access
Licence
Locations
  • Materials (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Universiti Putra Malaysia
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Keywords
bone tissue engineering, bone scaffolds, dielectric measurement, free-space measurement, non-destructive characterization, scaffold fabrication, scaffold mechanical properties, biocompatibility

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