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Cited by 306

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Synthesis, Characterization, and Antibacterial Activity of Cross-Linked Chitosan-Glutaraldehyde

Open access
Li, Bin, Shan, Chang-Lin, Zhou, Qing, Fang, Yuan, Wang, Yang-Li, Xu, Fei, Han, Li-Rong, Ibrahim, Muhammad, Guo, Long-Biao, Xie, Guan-Lin, Sun, Guo-Chang·2013·Marine Drugs

Abstract

This present study deals with synthesis, characterization and antibacterial activity of cross-linked chitosan-glutaraldehyde. Results from this study indicated that cross-linked chitosan-glutaraldehyde markedly inhibited the growth of antibiotic-resistant Burkholderia cepacia complex regardless of bacterial species and incubation time while bacterial growth was unaffected by solid chitosan. Furthermore, high temperature treated cross-linked chitosan-glutaraldehyde showed strong antibacterial activity against the selected strain 0901 although the inhibitory effects varied with different temperatures. In addition, physical-chemical and structural characterization revealed that the cross-linking of chitosan with glutaraldehyde resulted in a rougher surface morphology, a characteristic Fourier transform infrared (FTIR) band at 1559 cm−1, a specific X-ray diffraction peak centered at 2θ = 15°, a lower contents of carbon, hydrogen and nitrogen, and a higher stability of glucose units compared to chitosan based on scanning electron microscopic observation, FTIR spectra, X-ray diffraction pattern, as well as elemental and thermo gravimetric analysis. Overall, this study indicated that cross-linked chitosan-glutaraldehyde is promising to be developed as a new antibacterial drug.

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Crossref · 10.3390/md11051534

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Metadata

Authors
Li, B., Shan, C.-L., Zhou, Q., Fang, Y., Wang, Y.-L., Xu, F., Han, L.-R., Ibrahim, M., Guo, L.-B., Xie, G.-L., & Sun, G.-C.
Venue
Marine Drugs
Publisher
MDPI AG
Published
2013-05-13
Volume
11
Issue
5
Pages
1534-1552
ISSN
1660-3397 (ISSN-L)
OpenAlex
W1971680873
Cited by
306
References
34
FWCI
3.47
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Synthesis, Characterization, and Antibacterial Activity of Cross-Linked Chitosan-Glutaraldehyde. https://app.cochat.ai/papers/10.3390/md11051534
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Li, B., Shan, C.-L., Zhou, Q., Fang, Y., Wang, Y.-L., Xu, F., Han, L.-R., Ibrahim, M., Guo, L.-B., Xie, G.-L., & Sun, G.-C. (2013). Synthesis, Characterization, and Antibacterial Activity of Cross-Linked Chitosan-Glutaraldehyde. Marine Drugs. https://doi.org/10.3390/md11051534

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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