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Cited by 20Marine Sponges and Natural ProductsSynthesis and Biological ActivityMicrobial Natural Products and Biosynthesis

Tricyclic guanidine alkaloids from the marine sponge Acanthella cavernosa that stabilize the tumor suppressor PDCD4

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Grkovic, Tanja, Blees, Johanna, Bayer, Magdalena, Colburn, Nancy, Thomas, Cheryl, Henrich, Curtis, Peach, Megan, McMahon, James +2 more·2014·Marine Drugs
DOI 10.3390/md12084593PMC PMC4145332
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Abstract

A cell-based high-throughput screen that assessed the cellular stability of a tumor suppressor protein PDCD4 (Programmed cell death 4) was used to identify a new guanidine-containing marine alkaloid mirabilin K (3), as well as the known compounds mirabilin G (1) and netamine M (2). The structures of these tricyclic guanidine alkaloids were established from extensive spectroscopic analyses. Compounds 1 and 2 inhibited cellular degradation of PDCD4 with EC50 values of 1.8 μg/mL and 2.8 μg/mL, respectively. Mirabilin G (1) and netamine M (2) are the first marine natural products reported to stabilize PDCD4 under tumor promoting conditions.

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  • Tricyclic guanidine alkaloids from the marine animal sponge stabilize PDCD4 protein.

    “They have identified diaryl disulfides [98] and isolated tricyclic guanidine alkaloids from the marine animal sponge [99] as the PDCD4-protein stabilizer (Table 3).”

    From Control Mechanisms of the Tumor Suppressor PDCD4: Expression and Functions (2019) · cites this paper as [99]

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References 30 · Cited by 20

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Authors
Grkovic, T., Blees, J., Bayer, M., Colburn, N., Thomas, C., Henrich, C., Peach, M., McMahon, J., Schmid, T., & Gustafson, K.
Affiliations
  • National Cancer Institute (US)
  • Goethe University Frankfurt (DE)
  • Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany
  • Frederick National Laboratory for Cancer Research (US)
Corresponding author
Gustafson, Kirk
ORCID
Venue
Marine Drugs
Publisher
MDPI AG
Published
2014-08-21
Volume
12
Issue
8
Pages
4593-4601
ISSN
1660-3397 (ISSN-L)
DOI
10.3390/md12084593
PMC
PMC4145332
OpenAlex
W2075067705
Cited by
20
References
30
Citations by year
2025: 2 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 2
FWCI
1.70
Type
journal article
Language
en
Open access
Licence
Locations
  • Marine Drugs (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) (submittedVersion, cc-by)
Funders
  • Deutsche Forschungsgemeinschaft
  • National Institutes of Health (HHSN261200800001C)
  • National Cancer Institute (HHSN261200800001E))
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Synthesis and Biological Activity
  • Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
Keywords
marine sponge alkaloids, PDCD4, protein degradation inhibition, tumor promotion, marine natural products
MeSH terms
Alkaloids, Animals, Humans, Oleanolic Acid, Porifera, Saponins, RNA-Binding Proteins, Guanidine, Tumor Suppressor Proteins, Apoptosis Regulatory Proteins, HEK293 Cells

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