Marine Compounds and Cancer: 2017 Updates

Marine Compounds and Cancer: Where Do We Stand?

Dyshlovoy, S. A., & Honecker, F. U. (2015) · Marine Drugs · doi:10.3390/md13095657 · Cited by 56

Selenium-Containing Polysaccharide-Protein Complex in Se-Enriched Ulva fasciata Induces Mitochondria-Mediated Apoptosis in A549 Human Lung Cancer Cells

Sun, X. L., Zhong, Y., Luo, H., & Yang, Y. (2017) · Marine Drugs · doi:10.3390/md15070215 · Cited by 50

Paulomycin G, a New Natural Product with Cytotoxic Activity against Tumor Cell Lines Produced by Deep-Sea Sediment Derived Micromonospora matsumotoense M-412 from the Avilés Canyon in the Cantabrian Sea

Sarmiento-Vizcaíno, A., Braña, A. F., Pérez‐Victoria, I., Martı́n, J., de Pedro, N., de la Cruz, M., Díaz, C., Vicente, F., Acuña, J. L., Reyes, F., et al. (2017) · Marine Drugs · doi:10.3390/md15090271 · Cited by 48

Cembrene Diterpenoids with Ether Linkages from Sarcophyton ehrenbergi: An Anti-Proliferation and Molecular-Docking Assessment

Hegazy, M. F., Elshamy, A. I., Mohamed, T. A., Hamed, A. R., Ibrahim, M. A. A., Ohta, S., & Paré, P. W. (2017) · Marine Drugs · doi:10.3390/md15060192 · Cited by 45

Brevianamides and Mycophenolic Acid Derivatives from the Deep-Sea-Derived Fungus Penicillium brevicompactum DFFSCS025

Xu, X., Zhang, X., Nong, X., Wang, J., & Qi, S. (2017) · Marine Drugs · doi:10.3390/md15020043 · Cited by 41

Discovery of DNA Topoisomerase I Inhibitors with Low-Cytotoxicity Based on Virtual Screening from Natural Products

Xin, L.-T., Liu, L., Shao, C., Yu, R., Chen, F.-L., Yue, S., Wang, M., Guo, Z., Fan, Y.-C., Guan, H., et al. (2017) · Marine Drugs · doi:10.3390/md15070217 · Cited by 36

Fucoidan Does Not Exert Anti-Tumorigenic Effects on Uveal Melanoma Cell Lines

Dithmer, M., Kirsch, A. M., Richert, E., Fuchs, S., Wang, F., Schmidt, H., Coupland, S. E., Roider, J. B., & Klettner, A. (2017) · Marine Drugs · doi:10.3390/md15070193 · Cited by 30

The Marine Natural Product Pseudopterosin Blocks Cytokine Release of Triple-Negative Breast Cancer and Monocytic Leukemia Cells by Inhibiting NF-κB Signaling

Sperlich, J., Kerr, R. G., & Teusch, N. E. (2017) · Marine Drugs · doi:10.3390/md15090262 · Cited by 28

Sponges: A Reservoir of Genes Implicated in Human Cancer

Ćetković, H., Halasz, M., & Bosnar, M. H. (2018) · Marine Drugs · doi:10.3390/md16010020 · Cited by 26

Pleiotropic Role of Puupehenones in Biomedical Research

Martı́nez-Poveda, B., Quesada, A. R., & Medina, M. Á. (2017) · Marine Drugs · doi:10.3390/md15100325 · Cited by 19

Marine Natural Products: A Source of Novel Anticancer Drugs

Khalifa, S. A. M., Elias, N., Farag, M. A., Chen, L., Saeed, A., Hegazy, M.-E. F., Moustafa, M. S., Abd El-Wahed, A., Al-Mousawi, S. M., Musharraf, S. G., et al. (2019) · Marine Drugs · doi:10.3390/md17090491 · Cited by 555

Marine Natural Products in Clinical Use

Haque, N., Parveen, S., Tang, T., Wei, J., & Huang, Z. (2022) · Marine Drugs · doi:10.3390/md20080528 · Cited by 172

Marine-derived drugs: Recent advances in cancer therapy and immune signaling

Saeed, A. F. U. H., Su, J., & Ouyang, S. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.111091 · Cited by 142

Therapeutic value of steroidal alkaloids in cancer: Current trends and future perspectives

Dey, P. K., Kundu, A. B., Chakraborty, H. J., Kar, B., Choi, W. S., Lee, B. M., Bhakta, T., Atanasov, A. G., & Kim, H. S. (2018) · International Journal of Cancer · doi:10.1002/ijc.31965 · Cited by 124

Study of marine microorganism metabolites: new resources for bioactive natural products

Barzkar, N., Сухих, С. А., & Babich, O. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1285902 · Cited by 126

Marine Bioactive Peptides—An Overview of Generation, Structure and Application with a Focus on Food Sources

Pavlićević, M., Maestri, E., & Marmiroli, M. (2020) · Marine Drugs · doi:10.3390/md18080424 · Cited by 104

Recent Advances in Small Peptides of Marine Origin in Cancer Therapy

Zhang, Q., Liu, Z.-D., Wang, Z., Wang, T., Wang, N., Wang, N., Zhang, B., & Yu-fen, Z. (2021) · Marine Drugs · doi:10.3390/md19020115 · Cited by 76

Marine Compounds and Cancer: The First Two Decades of XXI Century

Dyshlovoy, S. A., & Honecker, F. U. (2019) · Marine Drugs · doi:10.3390/md18010020 · Cited by 67

MAPK signaling pathway-targeted marine compounds in cancer therapy

Wei, J., Liu, R., Hu, X., Liang, T., Zhou, Z., & Huang, Z. (2021) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-020-03460-y · Cited by 57

Anti-Tumorigenic and Anti-Metastatic Activity of the Sponge-Derived Marine Drugs Aeroplysinin-1 and Isofistularin-3 against Pheochromocytoma In Vitro

Bechmann, N., Ehrlich, H., Eisenhofer, G., Ehrlich, A., Meschke, S., Ziegler, C. G., & Bornstein, S. R. (2018) · Marine Drugs · doi:10.3390/md16050172 · Cited by 55

Marine Compounds and Cancer: Updates 2020

Dyshlovoy, S. A., & Honecker, F. U. (2020) · Marine Drugs · doi:10.3390/md18120643 · Cited by 53

Antitumor Potential of Seaweed Derived-Endophytic Fungi

Teixeira, T. R., dos Santos, G. S., Armstrong, L., Colepicolo, P., & Debonsi, H. M. (2019) · Antibiotics · doi:10.3390/antibiotics8040205 · Cited by 44

Antitumor Potential of Marine and Freshwater Lectins

Catanzaro, E., Calcabrini, C., Bishayee, A., & Fimognari, C. (2019) · Marine Drugs · doi:10.3390/md18010011 · Cited by 46

Highly Substituted Benzophenone Aldehydes and Eremophilane Derivatives from the Deep-Sea Derived Fungus Phomopsis lithocarpus FS508

Xu, J., Liu, H., Chen, Y., Tan, H., Guo, H., Xu, L., Li, S., Huang, Z., Li, H., Gao, X., et al. (2018) · Marine Drugs · doi:10.3390/md16090329 · Cited by 32

Natural Products as Regulators against Matrix Metalloproteinases for the Treatment of Cancer

Islam, M. T., Jang, N. H., & Lee, H. J. (2024) · Biomedicines · doi:10.3390/biomedicines12040794 · Cited by 32

Marine Compounds and Cancer: Updates 2022

Dyshlovoy, S. A., & Honecker, F. U. (2022) · Marine Drugs · doi:10.3390/md20120759 · Cited by 29

Marine-Derived Natural Products as ATP-Competitive mTOR Kinase Inhibitors for Cancer Therapeutics

Parate, S., Kumar, V., Lee, G., Rampogu, S. D., Hong, J. C., & Lee, K. W. (2021) · Pharmaceuticals · doi:10.3390/ph14030282 · Cited by 27

Secondary Metabolites from Marine Sources with Potential Use as Leads for Anticancer Applications

Veríssimo, A. C. S., Pacheco, M., Silva, A. M. S., & Pinto, D. C. G. A. (2021) · Molecules · doi:10.3390/molecules26144292 · Cited by 25

Oxidative stress mediates the inhibitory effects of Manzamine A on uterine leiomyoma cell proliferation and extracellular matrix deposition via SOAT inhibition

Lin, L.-C., Chang, H., Kuo, T., Chen, H.-Y., Liu, W., Lo, Y., Hsia, S., & Huang, T. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102861 · Cited by 25

Lithocarols A-F, six tenellone derivatives from the deep-sea derived fungus Phomopsis lithocarpus FS508

Xu, J., Liu, Z., Chen, Y., Tan, H., Li, H., Li, S., Guo, H., Huang, Z., Gao, X., Liu, H., et al. (2019) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2019.03.078 · Cited by 25

Carotenoids from Marine Microalgae as Antimelanoma Agents

Ferraz, C. A. A., Grougnet, R., Nicolau, É., Picot, L., & Júnior, R. G. D. O. (2022) · Marine Drugs · doi:10.3390/md20100618 · Cited by 24

Glycosylated Natural Products From Marine Microbes

Li, K., Cai, J. R., Su, Z., Yang, B., Liu, Y., Zhou, X., Huang, J., & Tao, H. (2020) · Frontiers in Chemistry · doi:10.3389/fchem.2019.00879 · Cited by 24

Flavonoids from Marine-Derived Actinobacteria as Anticancer Drugs

Hozzein, W. N., Mohany, M., Alhawsawi, S. M. M., Zaky, M. Y., Al-Rejaie, S. S., & Alkhalifah, D. H. M. (2021) · Current Pharmaceutical Design · doi:10.2174/1381612826666201216160154 · Cited by 23

Marine-Derived Biologically Active Compounds for the Potential Treatment of Rheumatoid Arthritis

Bilal, M., Qindeel, M., Nunes, L. V., Duarte, M. T. S., Ferreira, L. F. R., Soriano, R. N., & Iqbal, H. M. N. (2020) · Marine Drugs · doi:10.3390/md19010010 · Cited by 23

Efficacy and Mechanism of Action of Marine Alkaloid 3,10-Dibromofascaplysin in Drug-Resistant Prostate Cancer Cells

Dyshlovoy, S. A., Kaune, M., Hauschild, J., Kriegs, M., Hoffer, K., Busenbender, T., Smirnova, P. A., Zhidkov, M. E., Poverennaya, E. V., Oh‐Hohenhorst, S. J., et al. (2020) · Marine Drugs · doi:10.3390/md18120609 · Cited by 23

Pharmaceutical Potential of Marine Fungal Endophytes

Jeewon, R., Luckhun, A. B., Bhoyroo, V., Sadeer, N. B., Mahomoodally, M. F., Rampadarath, S., Puchooa, D., Sarma, V. V., Durairajan, S. S. K., & Hyde, K. D. (2019) · Reference series in phytochemistry · doi:10.1007/978-3-319-90484-9_6 · Cited by 21

Exploration of marine natural compounds as promising MDM2 inhibitors for treating triple-negative breast cancer: insights from molecular docking, ADME/T studies, molecular dynamics simulation and MM-PBSA binding free energy calculations

Ali, M. L., Hoque, N., Hasan, M. M., Azme, E., & Noushin, F. (2024) · Discover Chemistry. · doi:10.1007/s44371-024-00071-1 · Cited by 20

Anti-Tumor Activity vs. Normal Cell Toxicity: Therapeutic Potential of the Bromotyrosines Aerothionin and Homoaerothionin In Vitro

Drechsel, A., Helm, J., Ehrlich, H., Pantović, S., Bornstein, S. R., & Bechmann, N. (2020) · Marine Drugs · doi:10.3390/md18050236 · Cited by 16

Secondary Metabolites from Gorgonian Corals of the Genus Eunicella: Structural Characterizations, Biological Activities, and Synthetic Approaches

Matulja, D., Kolympadi, M., Ambrožič, G., Laclef, S., Pavelić, S. K., & Marković, D. (2019) · Molecules · doi:10.3390/molecules25010129 · Cited by 15

From seaside to bedside: Current evidence and future perspectives in the treatment of breast cancer using marine compounds

Sanctis, R. D., Jacobs, F., Benvenuti, C., Gaudio, M., Franceschini, R., Tancredi, R. J., Pedrazzoli, P., Santoro, A., & Zambelli, A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.909566 · Cited by 15

Blue-Print Autophagy in 2020: A Critical Review

Dyshlovoy, S. A. (2020) · Marine Drugs · doi:10.3390/md18090482 · Cited by 14

Marine Peptides: Structure, Bioactivities, and a New Hope for Therapeutic Application

Ovchinnikova, T. V. (2021) · Marine Drugs · doi:10.3390/md19080407 · Cited by 12

Natural Products of Marine Origin for the Treatment of Colorectal and Pancreatic Cancers: Mechanisms and Potential

Fares, N., & Luzzatto‐Knaan, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23148048 · Cited by 12

Marine Natural Products — a Vital Source of Novel Biotherapeutics

Begum, S. M. F. M., & Hemalatha, S. (2022) · Current Pharmacology Reports · doi:10.1007/s40495-022-00295-8 · Cited by 11

Comparative Analyses of Metabolomic Fingerprints and Cytotoxic Activities of Soft Corals from the Colombian Caribbean

Santacruz, L., Thomas, O., Carmenza Duque, B., Puyana, M., & Tello, E. (2019) · Marine Drugs · doi:10.3390/md17010037 · Cited by 10

Understanding the function of the tumor microenvironment, and compounds from marine organisms for breast cancer therapy

Malla, R. R., Farran, B., & Nagaraju, G. P. (2021) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v12.i2.15 · Cited by 10

Verminoside from Pseudolysimachion rotundum var. subintegrum sensitizes cisplatin-resistant cancer cells and suppresses metastatic growth of human breast cancer

Lee, C., Ryu, H. W., Kim, S., Kim, M., Oh, S., Ahn, K., & Park, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-77401-7 · Cited by 10

Orofacial antinociceptive effect of sulphated polysaccharide from the marine algae Hypnea pseudomusciformis in rodents

Souza, C. Á. P. B., de Oliveira, B. A., Santos, S. A. A. R., Batista, F. L. A., Andrade, F. R. N., Neto, E. J. R., Júnior, J. D. M. A. D. M., Mendes, F. R. D. S., Barroso, L. K. V., Canuto, K. M., et al. (2018) · Inflammopharmacology · doi:10.1007/s10787-018-0454-4 · Cited by 10

Advances in cancer therapy: unveil the immunomodulatory protein involved in signaling pathways as molecular targets

Selvaraj, C., Rajendran, S., Alothaim, A. S., Vijayakumar, R., Desai, D., Safi, S. Z., & Singh, S. K. (2025) · Chemical Papers · doi:10.1007/s11696-025-04007-6 · Cited by 8

Using nanotechnology to progress the utilization of marine natural products in combating multidrug resistance in cancer: A prospective strategy

Bhusare, N., Gade, A., & Kumar, M. S. (2024) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23732 · Cited by 7

Antimicrobial and cytotoxic effects of marine sponge extracts Agelas clathrodes , Desmapsamma anchorata and Verongula rigida from a Caribbean Island

Piron, J., Betzi, S., Pastour, J., Restouin, A., Castellano, R., Collette, Y., Tysklind, N., Smith‐Ravin, J., & Priam, F. (2022) · PeerJ · doi:10.7717/peerj.13955 · Cited by 6

Assessment of Knowledge, Perception, Attitude, Risk Factors Prevention, and Treatment Options of Cancer among Natives in Elgon Sub-Region, Uganda

Kudamba, A., Jamil, E. S., Okurut, S. A., Kafero, H. M., Nsubuga, H., & Walusansa, A. (2022) · Fortune Journal of Health Sciences · doi:10.26502/fjhs.074 · Cited by 6

Design, synthesis and antitumor activity evaluation of Chrysamide B derivatives

Zhu, L., Li, J., Fan, X., Hu, X., Chen, J., Liu, Y., Hao, X., Shi, T., Wang, Z., & Zhao, Q. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2021.104828 · Cited by 6

Anticancer potentiated bioactive compounds from marine flora

Ramu, A. K., Rajendran, R., Sivalingam, A. M., Seshadri, V. D., & Ahmed, A. B. A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-95086-2.00021-7 · Cited by 5

The Report of Marine Life Genomic ResearchPreprint

Fan, G., Chen, J., Jin, T., Shi, C., Du, X., Zhang, H., Zhang, Y., Li, H., Luo, T. L., Yan, P., et al. (2018) · Preprints.org · doi:10.20944/preprints201812.0156.v1 · Cited by 5

Therapeutic potential of Pseudopterosin H on a prostate cancer cell line

Bowers, Z., Caraballo, D., Bentley, A., Famuyiwa, T. O., Jebelli, J., Kumi-Diaka, J. K., & West, L. M. (2021) · Journal of Cancer Prevention & Current Research · doi:10.15406/jcpcr.2021.12.00459 · Cited by 4

Non-Pharmaceutical Interventions in Cancer Therapy

Tyagi, V., Tanwar, N., Kumar, N., Phogat, N., Kumar, P., & Kumar, V. (2024) · Current Cancer Therapy Reviews · doi:10.2174/0115733947268161240404084729 · Cited by 2

Screening of the antimicrobial activity of marine sponge extracts from MartiniquePreprint

Piron, J., Pastour, J., Tysklind, N., Smith‐Ravin, J., & Priam, F. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.16.431398 · Cited by 2

Marine Polysaccharide Nanocarriers: New Strategies for Targeted Cancer Therapy

Das, S., Murty, U. S., & Banerjee, S. (2026) · BioNanoScience · doi:10.1007/s12668-026-02610-9 · Cited by 1

Potential Natural Product Derived Compounds for Lung Cancer Therapy

Pithi Chanvorachote, B., Hutamekalin, P., Chunhacha, P., & Zin, Z. (2022) · Handbook of Oxidative Stress in Cancer: Therapeutic Aspects · doi:10.1007/978-981-16-1247-3_16-1

Peer Review #1 of "Antimicrobial and cytotoxic effects of marine sponge extracts Agelas clathrodes, Desmapsamma anchorata and Verongula rigida from a Caribbean Island (v0.2)"

(2022) · PeerJ · doi:10.7287/peerj.13955v0.2/reviews/1

Peer Review #1 of "Antimicrobial and cytotoxic effects of marine sponge extracts Agelas clathrodes, Desmapsamma anchorata and Verongula rigida from a Caribbean Island (v0.1)"

(2022) · PeerJ · doi:10.7287/peerj.13955v0.1/reviews/1

Peer Review #3 of "Antimicrobial and cytotoxic effects of marine sponge extracts Agelas clathrodes, Desmapsamma anchorata and Verongula rigida from a Caribbean Island (v0.2)"

(2022) · PeerJ · doi:10.7287/peerj.13955v0.2/reviews/3

Peer Review #2 of "Antimicrobial and cytotoxic effects of marine sponge extracts Agelas clathrodes, Desmapsamma anchorata and Verongula rigida from a Caribbean Island (v0.1)"

(2022) · PeerJ · doi:10.7287/peerj.13955v0.1/reviews/2

Peer Review #3 of "Antimicrobial and cytotoxic effects of marine sponge extracts Agelas clathrodes, Desmapsamma anchorata and Verongula rigida from a Caribbean Island (v0.1)"

(2022) · PeerJ · doi:10.7287/peerj.13955v0.1/reviews/3

Potential Natural Product–Derived Compounds for Lung Cancer Therapy

Pithi Chanvorachote, B., Hutamekalin, P., Chunhacha, P., & Zin, Z. (2022) · Handbook of Oxidative Stress in Cancer: Therapeutic Aspects · doi:10.1007/978-981-16-5422-0_16

Étude génétique et moléculaire d'éponges marines de la Martinique

Piron, J. (2021) · theses.fr (ABES) · doi:10.70675/dcf20327z74e4z4595z9839z5758bc9f3ceb

Sensibilisation de cellules de mélanome à la chimiothérapie par des flavonoïdes et caroténoïdes extraits de plantes du Brésil, de Nouvelle-Calédonie et de microalgues marines

Júnior, R. G. D. O. (2020) · theses.fr (ABES) · doi:10.70675/0d3e313azade2z4056z8bc0z7524e19b4132

The Marine Pharmacology and Pharmaceuticals Pipeline in 2017

Trieu, J., Newman, D. J., Glaser, K. B., & Mayer, A. M. S. (2018) · The FASEB Journal · doi:10.1096/fasebj.2018.32.1_supplement.702.2 · Cited by 3

The 2021 Marine Pharmacology and Pharmaceuticals Pipeline

Wu, A. C., Jelielek, K. K., Le, H. Q., Butt, M., Newman, D. J., Glaser, K. B., Pierce, M. L., & Mayer, A. M. S. (2022) · The FASEB Journal · doi:10.1096/fasebj.2022.36.s1.l7586 · Cited by 4

Marine-Derived Pharmaceuticals in Clinical Trials in 2022

Mayer, A. M. S., Pierce, M. L., Reji, M., Wu, A. C., Jekielek, K. K., Le, H. Q., Howe, K., Butt, M., Seo, S., Newman, D. J., et al. (2023) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.122.527010 · Cited by 6

The Marine Pharmacology and Pharmaceuticals Pipeline in 2020

Jekielek, K. K., Le, H. Q., Wu, A. C., Newman, D. J., Glaser, K. B., & Mayer, A. M. S. (2021) · The FASEB Journal · doi:10.1096/fasebj.2021.35.s1.00209 · Cited by 8

Marine Compounds and Cancer: Updates 2020

Dyshlovoy, S. A., & Honecker, F. U. (2020) · Marine Drugs · doi:10.3390/md18120643 · Cited by 53