Fucoidan in pharmaceutical formulations: A comprehensive review for smart drug delivery systems
Open accessAbstract
Fucoidan is a heterogeneous group of polysaccharides isolated from marine organisms, including brown algae and marine invertebrates. The physicochemical characteristics and potential bioactivities of fucoidan have attracted substantial interest in pharmaceutical industries in the past few decades. These polysaccharides are characterized by possessing sulfate ester groups that impart negatively charged surfaces, low/high molecular weight, and water solubility. In addition, various promising bioactivities have been reported, such as antitumor, immunomodulatory, and antiviral effects. Hence, the formulation of fucoidan has been investigated in the past few years in diverse pharmaceutical dosage forms to be able to reach their site of action effectively. Moreover, they can act as carriers for various drugs in value-added drug delivery systems. The current work highlights the attractive biopharmaceutical properties of fucoidan being formulated in oral, inhalable, topical, injectable, and other advanced formulations treating life-quality-affecting diseases. Therefore, the present work points out the current status of fucoidan pharmaceutical formulations for future research transferring their application from in vitro and in vivo studies to clinical application and market availability.
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Due to its large number of negatively charged sulfonic acidic groups, fucoidan is considered to be pH sensitive.
“Due to its large number of negatively charged sulfonic acidic groups, fucoidan is considered to be pH sensitive (Wang et al., 2022; Haggag et al., 2023).”
From pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery. (2023) · cites this paper as Haggag et al., 2023
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References 135 · Cited by 126
Research works printed but not linked: 1
- [131]Reis A. Da Silva T.L. Scale-up Problems for the Large Scale Production of Algae Algal Biorefinery: An Integrated Approach Springer Kharagpur, India 2016 125 149 9783319228136
- Authors
- Haggag, Y., Abd Elrahman, A., Ulber, R., & Zayed, A.
- Affiliations
- Tanta University (EG)
- Department of Pharmaceutical Technology, Faculty of Pharmacy, Tanta University, El-Geish Street, Tanta 31527, Egypt
- Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau (DE)
- Corresponding author
- Zayed, Ahmed
- Venue
- Marine Drugs
- Publisher
- MDPI AG
- Published
- 2023-02-04
- Volume
- 21
- Issue
- 2
- Pages
- 112
- ISSN
- 1660-3397 (ISSN-L)
- PMC
- PMC9965894
- OpenAlex
- W4319320259
- Cited by
- 126
- References
- 135
- Citations by year
- 2026: 37 · 2025: 44 · 2024: 28 · 2023: 17
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Marine Drugs (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ministry of Higher Education (31111)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Keywords
- fucoidan, polysaccharides, drug delivery systems, drug formulation, brown algae, marine invertebrates, anticancer activity, immunomodulation, antiviral activity, oral dosage forms, topical formulation, injectable formulation, biopharmaceuticals
- MeSH terms
- Drug Compounding, Pharmaceutical Preparations, Polysaccharides, Drug Delivery Systems, Aquatic Organisms
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