Actinomycetes for marine drug discovery isolated from mangrove soils and plants in China
Open accessAbstract
The mangrove ecosystem is a largely unexplored source for actinomycetes with the potential to produce biologically active secondary metabolites. Consequently, we set out to isolate, characterize and screen actinomycetes from soil and plant material collected from eight mangrove sites in China. Over 2,000 actinomycetes were isolated and of these approximately 20%, 5%, and 10% inhibited the growth of Human Colon Tumor 116 cells, Candida albicans and Staphylococcus aureus, respectively, while 3% inhibited protein tyrosine phosphatase 1B (PTP1B), a protein related to diabetes. In addition, nine isolates inhibited aurora kinase A, an anti-cancer related protein, and three inhibited caspase 3, a protein related to neurodegenerative diseases. Representative bioactive isolates were characterized using genotypic and phenotypic procedures and classified to thirteen genera, notably to the genera Micromonospora and Streptomyces. Actinomycetes showing cytotoxic activity were assigned to seven genera whereas only Micromonospora and Streptomyces strains showed anti-PTP1B activity. We conclude that actinomycetes isolated from mangrove habitats are a potentially rich source for the discovery of anti-infection and anti-tumor compounds, and of agents for treating neurodegenerative diseases and diabetes.
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References 89 · Cited by 372
Research works printed but not linked: 2
- [40]Hong K Yan B Uncultured microorganisms in Hainan mangrove soil: diversity and functional genes “Microbes and the Environment: Perspective and Challenges” Liu SJ Drake HL Science Press Beijing, China 2008 52 58
- [60]Ivantiskaya LP Singal SM Bibikova MV Vostrov SN Direct isolation of Micromonospora on selective media with gentamicin Antibiotiki 1978 23 690 692 686691
- Authors
- Hong, K., Gao, A.-H., Xie, Q.-Y., Gao, H. G., Zhuang, L., Lin, H.-P., Yu, H.-P., Li, J., Yao, X.-S., Goodfellow, M., & Ruan, J.-S.
- Affiliations
- Chinese Academy of Tropical Agricultural Sciences (CN)
- Shanghai Institute of Materia Medica (CN)
- Jinan University (CN)
- Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou 571101, P.R.China
- Newcastle University (GB)
- Corresponding author
- Hong, Kui
- Venue
- Marine Drugs
- Publisher
- MDPI AG
- Published
- 2009-01-03
- Volume
- 7
- Issue
- 1
- Pages
- 24-44
- ISSN
- 1660-3397 (ISSN-L)
- PMC
- PMC2666887
- OpenAlex
- W2110105875
- Cited by
- 372
- References
- 89
- Citations by year
- 2026: 9 · 2025: 20 · 2024: 16 · 2023: 17 · 2022: 23 · 2021: 20 · 2020: 33 · 2019: 30 · 2018: 24 · 2017: 27 · 2016: 23 · 2015: 26 · 2014: 22 · 2013: 20 · 2012: 27
- FWCI
- 14.86
- Type
- journal article
- Language
- en
- Update notices
- correction (2009-01-03)
- Open access
- gold
- doi.org
- Licence
- Locations
- Marine Drugs (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- National Natural Science Foundation of China (U0633008)
- Program for New Century Excellent Talents in University
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Metabolism and Applications
- Keywords
- actinomycetes, mangrove soil, mangroves, marine drug discovery, secondary metabolites, anticancer activity, antifungal activity, antibacterial activity, PTP1B inhibition, caspase-3 inhibition, Micromonospora, Streptomyces, cytotoxicity, antidiabetic drugs, neurodegenerative diseases
- MeSH terms
- Animals, Anti-Infective Agents, Antineoplastic Agents, Candida albicans, China, Drug Screening Assays, Antitumor, Hypoglycemic Agents, Microbiological Techniques, Phylogeny, Soil Microbiology, Staphylococcus aureus, Tumor Cells, Cultured, Protein Serine-Threonine Kinases, Ecosystem, Magnoliopsida, Actinobacteria, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Drug Discovery, Caspase Inhibitors, Aurora Kinase A, Aurora Kinases
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