Anthracenedione derivatives as anticancer agents isolated from secondary metabolites of the mangrove endophytic fungi
Open accessAbstract
In this article, we report anticancer activity of 14 anthracenedione derivatives separated from the secondary metabolites of the mangrove endophytic fungi Halorosellinia sp. (No. 1403) and Guignardia sp. (No. 4382). Some of them inhibited potently the growth of KB and KBv200 cells, among which compound 6 displayed strong cytotoxicity with IC50 values of 3.17 and 3.21 μM to KB and KBv200 cells, respectively. Furthermore, we demonstrate that the mechanism involved in the apoptosis induced by compound 6 is probably related to mitochondrial dysfunction. Additionally, the structure-activity relationships of these compounds are discussed.
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References 33 · Cited by 103
- Authors
- Zhang, J.-Y., Tao, L.-Y., Liang, Y.-J., Chen, L.-M., Mi, Y.-J., Zheng, L.-S., Wang, F., She, Z.-G., Lin, Y.-C., To, K. K. W., & Fu, L.-W.
- Affiliations
- State Key Laboratory for Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou, 510060, China
- Sun Yat-sen University (CN)
- Chinese University of Hong Kong (HK)
- Corresponding author
- She, Zhi-gang
- Venue
- Marine Drugs
- Publisher
- MDPI AG
- Published
- 2010-04-23
- Volume
- 8
- Issue
- 4
- Pages
- 1469-1481
- ISSN
- 1660-3397 (ISSN-L)
- PMC
- PMC2866493
- OpenAlex
- W2066539709
- Cited by
- 103
- References
- 33
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 8 · 2022: 10 · 2021: 9 · 2020: 9 · 2019: 8 · 2018: 4 · 2017: 6 · 2016: 7 · 2015: 1 · 2014: 8 · 2013: 12 · 2012: 4
- FWCI
- 5.43
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Marine Drugs (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- State Key Laboratory of Oncology in South China
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Natural Compound Pharmacology Studies
- Keywords
- anthracenedione derivatives, anticancer agents, mangrove endophytic fungi, Guignardia, secondary metabolites, KB cells, KBv200 cells, cytotoxicity, apoptosis, mitochondrial dysfunction, structure-activity relationship
- MeSH terms
- Anthraquinones, Antineoplastic Agents, Drug Screening Assays, Antitumor, Fungi, Humans, KB Cells, Mitochondria, Structure-Activity Relationship, Apoptosis, Inhibitory Concentration 50, Rhizophoraceae
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