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Cited by 18Gestational Diabetes Research and ManagementBirth, Development, and HealthMaternal and Neonatal Healthcare

Gestational Diabetes and Risk Assessment of Adverse Perinatal Outcomes and Newborns Early Motoric Development

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Lackovic, Milan, Milicic, Biljana, Mihajlovic, Sladjana, Filimonovic, Dejan, Jurisic, Aleksandar, Filipovic, Ivana, Rovcanin, Marija, Prodanovic, Maja +1 more·2021·Medicina
DOI 10.3390/medicina57080741PMC PMC8401518
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Abstract

Background and Objectives: The aim of this study was to analyze the presence of gestational diabetes mellitus (GDM) on maternal and fetal perinatal parameters, as well to evaluate the influence of GDM on neonatal early motoric development. Materials and Methods: In this prospective study, we evaluated 203 eligible participants that were admitted to obstetrics department for a labor. GDM was assessed by evaluation of maternal parameters, fetal parameters, as well its impact on infants early motoric development (Alberta Infant Motor Scale—AIMS). Results: Presence of GDM was significantly positively associated with: pre-pregnancy weight, obesity degree, weight at delivery, gestational weight gain (GWG), body mass index (BMI) at delivery, GWG and increased pre-pregnancy BMI, glucose levels in mother’s venous blood after the delivery, positive family history for cardiovascular disease, pregnancy-related hypertension, congenital thrombophilia, drug use in pregnancy, large for gestational age (LGA), mode of delivery (Cesarean section and instrumental delivery). Likewise, GDM association was detected for tested ultrasound parameters (biparietal diameter (BPD), head circumference (HC), abdominal circumference (AC), femoral length (FL)), length at birth, birth weight, newborn’s head circumference, newborn’s chest circumference, AIMS supination and pronation at three months, AIMS supination, pronation, sitting and standing at six months. Only Amniotic Fluid Index and AIMS supination at three months of infant’s age remained significantly associated in multivariate regression model. Conclusions: The presence of significant positive association of numerous tested parameters in our study on perinatal outcomes and early motoric development, points to the necessity of establishing appropriate clinical decision-making strategies for all pregnant woman at risk and emphasize the importance of providing adequate glycaemia control options and further regular follow ups during the pregnancy.

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  • In Serbia, Lackovic et al. assessed GDM incidence at 24.6% and found positive correlations between GDM and BMI at delivery, gestational weight gain, pre-pregnancy BMI, positive family history for cardiovascular disease, LGA, mode of delivery, congenital thrombophilia, and hypertension in pregnancy.

    “Lackovic et al. assessed the incidence of GDM at 24.6%. In addition, they found positive correlations between GDM and BMI at delivery, gestational weight gain (GWG), pre-pregnancy BMI, positive family history for cardiovascular disease, LGA, mode of delivery, congenital thrombophilia, and hypertension in pregnancy [190].”

    From Evolution of Gestational Diabetes Mellitus across Continents in 21st Century (2022) · cites this paper as [190]

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  • In Serbia, ADA or IADPSG criteria for GDM diagnosis are used; earlier, 100 g OGTT was used in high-risk patients.

    “In Serbia the ADA or IADPSG criteria for GDM diagnosis are used [189,190,191]. Earlier, the 100 g OGTT was used in high-risk patients [189].”

    From Evolution of Gestational Diabetes Mellitus across Continents in 21st Century (2022) · cites this paper as [190]

    Methods §2.1 reports that this Serbian study diagnosed GDM using ADA recommendations and a 75 g OGTT, with higher-risk patients screened earlier in pregnancy. It does not report earlier use of a 100 g OGTT in high-risk patients or establish that IADPSG criteria are used in Serbia. (LLM, conf=0.88)

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Authors
Lackovic, M., Milicic, B., Mihajlovic, S., Filimonovic, D., Jurisic, A., Filipovic, I., Rovcanin, M., Prodanovic, M., & Nikolic, D.
Affiliations
  • Clinical Hospital Center “Dr. Dragiša Mišović”, 11000 Belgrade, Serbia
  • Faculty of Dental Medicine, University of Belgrade, 11000 Belgrade, Serbia
  • University of Belgrade (RS)
  • Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia
  • Cardiology Clinic, Emergency Center, University Clinical Center of Serbia, 11000 Belgrade, Serbia
ORCID
Venue
Medicina
Publisher
MDPI AG
Published
2021-07-22
Volume
57
Issue
8
Pages
741
ISSN
  • 1010-660X (ISSN-L)
  • 1648-9144
DOI
10.3390/medicina57080741
PMC
PMC8401518
OpenAlex
W3185230190
Cited by
18
References
3
Citations by year
2026: 4 · 2025: 1 · 2024: 3 · 2023: 6 · 2022: 3 · 2021: 1
FWCI
2.95
Type
journal article
Language
en
Open access
Licence
Locations
  • Medicina (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Health Professions › General Health Professions › Maternal and Neonatal Healthcare
Keywords
gestational diabetes mellitus, perinatal outcomes, neonatal motor development, Alberta Infant Motor Scale, birth weight, gestational weight gain, maternal obesity, pre-pregnancy body mass index, large for gestational age, cesarean section, amniotic fluid index
MeSH terms
Gestational Weight Gain, Cesarean Section, Female, Humans, Infant, Newborn, Pregnancy, Prospective Studies, Body Mass Index, Diabetes, Gestational, Risk Assessment

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