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Cited by 42Microbial Metabolic Engineering and BioproductionGene Regulatory Network AnalysisBacterial Genetics and Biotechnology

Multifaceted Applications of Synthetic Microbial Communities: Advances in Biomedicine, Bioremediation, and Industry

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Contreras-Salgado, Edgar Adrian, Sánchez-Morán, Ana Georgina, Rodríguez-Preciado, Sergio Yair, Sifuentes-Franco, Sonia, Rodríguez-Rodríguez, Rogelio, Macías-Barragán, José, Díaz-Zaragoza, Mariana·2024·Microbiology Research
DOI 10.3390/microbiolres15030113
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Abstract

The broad range of applications offered by synthetic biology and bioengineering has revolutionized the ability to design and redesign microorganisms to express specific functions, overcoming the limitations of natural biological systems. This advancement has been achieved through the use of mathematical models and genetic circuits, enabling the precise design of synthetic microbial communities. These are defined as artificially created communities through co-cultures of selected species that share similar characteristics and environments. Reprogramming an organism is carried out by inserting synthetic genetic circuits, which are designed in a controlled manner to obtain biotechnological products beneficial to humans, their health, and the environment. The potential applications in medicine, bioremediation, industry, and pharmaceuticals make the research of synthetic microbial communities a promising field for the future. However, the implementation of synthetic microbial communities carries potential risks, such as horizontal gene transfer and possible environmental impacts. It is crucial to carefully evaluate these functions and risks, considering biocontainment and the associated ethical and ecological implications.

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  • Synthetic microbial consortia have been explored to enhance biodegradation, yet their success in real-world applications remains limited by challenges in controlling their behavior outside controlled laboratory settings.

    “In addition, synthetic microbial consortia have been explored to enhance biodegradation, yet their success in real-world applications remains limited by challenges in controlling their behavior outside of controlled laboratory settings [74].”

    From Harnessing bacterial consortia for effective bioremediation: targeted removal of heavy metals, hydrocarbons, and persistent pollutants (2025) · cites this paper as [74]

    Section 5.2 (Bioremediation and Industry; page not available) describes synthetic consortia constructed to degrade oil and reports improved degradation under optimal conditions. Sections 2.1 and 6 discuss controllability under laboratory conditions and risks of implementation, but the paper does not establish that difficulty controlling behavior outside the lab has limited real-world biodegradation success. (LLM, conf=0.84)

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Cited by

Sorted by citations

Authors
Contreras-Salgado, E. A., Sánchez-Morán, A. G., Rodríguez-Preciado, S. Y., Sifuentes-Franco, S., Rodríguez-Rodríguez, R., Macías-Barragán, J., & Díaz-Zaragoza, M.
Affiliations
  • Universidad de Guadalajara (MX)
  • Laboratorio de Sistemas Biológicos, Departamento de Ciencias de la Salud, Centro Universitario de los Valles, Universidad de Guadalajara, Carretera Guadalajara-Ameca Km. 45.5, Ameca, Jalisco 466000, Mexico
  • Laboratorio de Ciencia Básica, Departamento de Ciencias Naturales y Exactas, Centro Universitario de los Valles, Universidad de Guadalajara, Carretera Guadalajara-Ameca Km. 45.5, Ameca, Jalisco 466000, Mexico
Corresponding author
Díaz-Zaragoza, Mariana
ORCID
Venue
Microbiology Research
Publisher
MDPI AG
Published
2024-08-29
Volume
15
Issue
3
Pages
1709-1727
ISSN
  • 2036-7473 (ISSN-L)
  • 2036-7481
DOI
10.3390/microbiolres15030113
OpenAlex
W4401994297
Cited by
42
References
0
Citations by year
2026: 24 · 2025: 17 · 2024: 1
FWCI
5.43
Type
journal article
Language
en
Open access
Licence
Locations
  • Microbiology Research (publishedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Fomento a la Investigación 2023–2024 Centro Universitario de los Valles (CUVALLES)-Universidad de Guadalajara (274321)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords
synthetic microbial communities, synthetic biology, synthetic gene circuits, co-culture, biomedicine, bioremediation, bioengineering, horizontal gene transfer, biocontainment

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