The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Targeting Biofilms Therapy: Current Research Strategies and Development Hurdles
Open accessAbstract
Biofilms are aggregate of microorganisms in which cells are frequently embedded within a self-produced matrix of extracellular polymeric substance (EPS) and adhere to each other and/or to a surface. The development of biofilm affords pathogens significantly increased tolerances to antibiotics and antimicrobials. Up to 80% of human bacterial infections are biofilm-associated. Dispersal of biofilms can turn microbial cells into their more vulnerable planktonic phenotype and improve the therapeutic effect of antimicrobials. In this review, we focus on multiple therapeutic strategies that are currently being developed to target important structural and functional characteristics and drug resistance mechanisms of biofilms. We thoroughly discuss the current biofilm targeting strategies from four major aspects—targeting EPS, dispersal molecules, targeting quorum sensing, and targeting dormant cells. We explain each aspect with examples and discuss the main hurdles in the development of biofilm dispersal agents in order to provide a rationale for multi-targeted therapy strategies that target the complicated biofilms. Biofilm dispersal is a promising research direction to treat biofilm-associated infections in the future, and more in vivo experiments should be performed to ensure the efficacy of these therapeutic agents before being used in clinic.
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Cites
Biofilms: an emergent form of bacterial life
Flemming, H.-C., Wingender, J., Szewzyk, U., Steinberg, P., Rice, S. A., & Kjelleberg, S. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.94 · Cited by 5,979
Pseudomonas aeruginosa Displays Multiple Phenotypes during Development as a Biofilm
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A component of innate immunity prevents bacterial biofilm development
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Biofilm Dispersal: Mechanisms, Clinical Implications, and Potential Therapeutic Uses
Kaplan, J. B. (2010) · Journal of Dental Research · doi:10.1177/0022034509359403 · Cited by 949
Should we stay or should we go: mechanisms and ecological consequences for biofilm dispersal
McDougald, D., Rice, S. A., Barraud, N., Steinberg, P. D., & Kjelleberg, S. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2695 · Cited by 881
d -Amino Acids Trigger Biofilm Disassembly
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Enzymatic Detachment of Staphylococcus epidermidis Biofilms
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Cited by
Sharma, S., Mohler, J., Mahajan, S. D., Schwartz, S. A., Bruggemann, L., & Aalinkeel, R. (2023) · Microorganisms · doi:10.3390/microorganisms11061614 · Cited by 993
Imaging Flow Cytometry to Study Biofilm-Associated Microbial Aggregates
Konieczny, M., Rhein, P., Czaczyk, K., Białas, W., & Juzwa, W. (2021) · Molecules · doi:10.3390/molecules26237096 · Cited by 20
Metadata
- Authors
- Jiang, Y., Geng, M., & Bai, L.
- Venue
- Microorganisms
- Publisher
- MDPI AG
- Published
- 2020-08-11
- Volume
- 8
- Issue
- 8
- Pages
- 1222
- ISSN
- 2076-2607 (ISSN-L)
- OpenAlex
- W3048524471
- Cited by
- 195
- References
- 12
- FWCI
- 5.74
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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