The DOI matches its Crossref record; 89 of the 89 references it cites were found in a registry or an index.
5-Fluorouracil: Mechanisms of Resistance and Reversal Strategies
Open accessAbstract
The purpose of this work is to review the published studies on the mechanisms of action and resistance of 5-fluorouracil. The review is divided into three main sections: mechanisms of anti-tumor action, studies of the resistance to the drug, and procedures for the identification of new genes involved in resistance with microarray techniques. The details of the induction and reversal of the drug resistance are also described.
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Cites
5-Fluorouracil: mechanisms of action and clinical strategies
Longley, D. B., Harkin, D. P., & Johnston, P. G. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1074 · Cited by 5,332
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Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.
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Molecular mechanisms of drug resistance
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NF-κB is a target of AKT in anti-apoptotic PDGF signalling
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Giacchetti, S., Perpoint, B., Zidani, R., Le Bail, N., Faggiuolo, R., Focan, C., Chollet, P., Llory, J. F., Letourneau, Y., Coudert, B., et al. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.1.136 · Cited by 1,403
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Chemogenomic profiling: Identifying the functional interactions of small molecules in yeast
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Thymidylate synthetase - a target enzyme in cancer chemotherapy
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Lum, P. Y., Armour, C. D., Stepaniants, S. B., Cavet, G., Wolf, M. K., Butler, J. S., Hinshaw, J. C., Garnier, P., Prestwich, G. D., Leonardson, A., et al. (2004) · Cell · doi:10.1016/s0092-8674(03)01035-3 · Cited by 481
Cited by
Drug resistance in cancer: An overview
Housman, G., Byler, S., Heerboth, S., Lapinska, K., Longacre, M., Snyder, N., & Sarkar, S. (2014) · Cancers · doi:10.3390/cancers6031769 · Cited by 2,463
Blondy, S., David, V., Verdier, M., Mathonnet, M., Perraud, A., & Christou, N. (2020) · Cancer Science · doi:10.1111/cas.14532 · Cited by 507
5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation
Cho, Y.-H., Ro, E. J., Yoon, J.-S., Mizutani, T., Kang, D.-W., Park, J.-C., Il Kim, T., Clevers, H., & Choi, K.-Y. (2020) · Nature Communications · doi:10.1038/s41467-020-19173-2 · Cited by 336
Däster, S., Amatruda, N., Calabrese, D., Ivanek, R., Turrini, E., Droeser, R. A., Zajac, P., Fimognari, C., Spagnoli, G. C., Iezzi, G., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.13857 · Cited by 281
Quan, Q., Zhong, F., Wang, X., Chen, K., & Guo, L. (2019) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/096504018x15442985680348 · Cited by 29
Metadata
- Authors
- Zhang, N., Yin, Y., Xu, S.-J., & Chen, W.-S.
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2008-08-05
- Volume
- 13
- Issue
- 8
- Pages
- 1551-1569
- ISSN
- 1420-3049 (ISSN-L)
- OpenAlex
- W2130392703
- Cited by
- 771
- References
- 89
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: 5-Fluorouracil: Mechanisms of Resistance and Reversal Strategies. https://app.cochat.ai/papers/10.3390/molecules13081551
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- Zhang, N., Yin, Y., Xu, S.-J., & Chen, W.-S. (2008). 5-Fluorouracil: Mechanisms of Resistance and Reversal Strategies. Molecules. https://doi.org/10.3390/molecules13081551
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
