The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Chemical and Pharmacological Aspects of Capsaicin
Open accessAbstract
Capsaicin is a unique alkaloid found primarily in the fruit of the Capsicum genus and is what provides its spicy flavor. Generally extracted directly from fruit, high demand has driven the use of established methods to increase production through extraction and characterization. Over time these methods have improved, usually be applying existing techniques in conjunction. An increasingly wide range of potential applications has increased interest in capsaicin. Especially compelling are the promising results of medical studies showing possible beneficial effects in many diseases. Capsaicin’s pungency has limited its use in clinical trials to support its biological activity. Characterization and extraction/ synthesis of non-pungent analogues is in progress. A review is made of capsaicin research focusing mainly on its production, synthesis, characterization and pharmacology, including some of its main potential clinical uses in humans.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The capsaicin receptor: a heat-activated ion channel in the pain pathway
Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., & Julius, D. (1997) · Nature · doi:10.1038/39807 · Cited by 9,107
Materska, M., & Perucka, I. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf035331k · Cited by 604
Sensory neuron-specific actions of capsaicin: mechanisms and applications
Bevan, S., & Szolcsányi, J. (1990) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(90)90237-3 · Cited by 446
Structure and function of TRPV1
Tominaga, M., & Tominaga, T. (2005) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-005-1457-8 · Cited by 415
Biochemical pharmacology of the vanilloid receptor TRPV1: An update
Cortright, D. N., & Szallasi, A. (2004) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.2004.04082.x · Cited by 331
The Pun1 gene for pungency in pepper encodes a putative acyltransferase
Stewart, C., Kang, B., Liu, K., Mazourek, M., Moore, S. L., Yoo, E. Y., Kim, B., Paran, I., & Jahn, M. M. (2005) · The Plant Journal · doi:10.1111/j.1365-313x.2005.02410.x · Cited by 329
Effects of Capsaicin on Lipid Metabolism in Rats Fed a High Fat Diet
Kawada, T., Hagihara, K.-I., & Iwai, K. (1986) · The Journal of Nutrition · doi:10.1093/jn/116.7.1272 · Cited by 307
Tissue distribution & elimination of capsaicin, piperine & curcumin following oral intake in rats.
Suresh, D., & Srinivasan, K. (2010) · PubMed · Cited by 272
Capsaicin Receptor: TRPV1 A Promiscuous TRP Channel
Pingle, S. C., Matta, J. A., & Ahern, G. P. (2007) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-540-34891-7_9 · Cited by 238
Ultrasound-assisted extraction of capsaicinoids from peppers
BARBERO, G., LIAZID, A., PALMA, M., & BARROSO, C. (2008) · Talanta · doi:10.1016/j.talanta.2008.01.046 · Cited by 234
Cited by
Role of plant alkaloids on human health: A review of biological activities
Debnath, B., Singh, W. S., Das, M., Goswami, S., Singh, M. K., Maiti, D., & Manna, K. (2018) · Materials Today Chemistry · doi:10.1016/j.mtchem.2018.05.001 · Cited by 384
Batiha, G. E.-S., Alqahtani, A., Ojo, O. A., Shaheen, H. M., Wasef, L., Elzeiny, M., Ismail, M., Shalaby, M., Murata, T., Zaragoza-Bastida, A., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155179 · Cited by 259
Glial functions in the blood-brain communication at the circumventricular organs
Miyata, S. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.991779 · Cited by 66
Supercritical fluids and fluid mixtures to obtain high-value compounds from Capsicum peppers
De Aguiar, A. C., Viganó, J., da Silva Anthero, A. G., Dias, A. L. B., Hubinger, M. D., & Martínez, J. (2022) · Food Chemistry: X · doi:10.1016/j.fochx.2022.100228 · Cited by 45
Metadata
- Authors
- Reyes-Escogido, M. D. L., Gonzalez-Mondragon, E. G., & Vazquez-Tzompantzi, E.
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2011-01-28
- Volume
- 16
- Issue
- 2
- Pages
- 1253-1270
- ISSN
- 1420-3049 (ISSN-L)
- OpenAlex
- W2152181954
- Cited by
- 494
- References
- 38
- FWCI
- 18.56
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Chemical and Pharmacological Aspects of Capsaicin. https://app.cochat.ai/papers/10.3390/molecules16021253
- The paper
- Reyes-Escogido, M. D. L., Gonzalez-Mondragon, E. G., & Vazquez-Tzompantzi, E. (2011). Chemical and Pharmacological Aspects of Capsaicin. Molecules. https://doi.org/10.3390/molecules16021253
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
