Enhancing the therapeutic delivery of oligonucleotides by chemical modification and nanoparticle encapsulation
Open accessAbstract
Oligonucleotide (ON) drugs, including small interfering RNA (siRNA), microRNA (miRNA) and antisense oligonucleotides, are promising therapeutic agents. However, their low membrane permeability and sensitivity to nucleases present challenges to in vivo delivery. Chemical modifications of the ON offer a potential solution to improve the stability and efficacy of ON drugs. Combined with nanoparticle encapsulation, delivery at the site of action and gene silencing activity of chemically modified ON drugs can be further enhanced. In the present review, several types of ON drugs, selection of chemical modification, and nanoparticle-based delivery systems to deliver these ON drugs are discussed.
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Modified siRNA remain intact for long durations under circulation, providing the possibility of delivering siRNA without nanoparticle shielding.
“With the development of chemical modifications on RNA molecules, modified siRNA are reported to remain intact for long durations under circulation, which provides the possibility of delivering siRNA without the shielding of nanoparticles.[19, 75, 76]”
From RNA delivery biomaterials for the treatment of genetic and rare diseases (2019) · cites this paper as [76]
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References 105 · Cited by 56
- Authors
- Sun, Y., Zhao, Y., Zhao, X., Lee, R. J., Teng, L., & Zhou, C.
- Affiliations
- Jilin University (CN)
- Tavistock Life Sciences, San Diego, CA 92130, USA
- Corresponding author
- Teng, Lesheng
- Zhou, Chenguang
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2017-10-13
- Volume
- 22
- Issue
- 10
- Pages
- 1724
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC6158866
- OpenAlex
- W2763272720
- Cited by
- 56
- References
- 105
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 8 · 2023: 10 · 2022: 5 · 2021: 5 · 2020: 9 · 2019: 7 · 2018: 3
- FWCI
- 0.49
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81502999)
- Special Financial Grant from the China Postdoctoral Science Foundation (2017T100374)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- oligonucleotides, siRNA, microRNA, antisense oligonucleotides, chemical modification, nanoparticle encapsulation, nanoparticle drug delivery, gene silencing, nuclease resistance, membrane permeability, oligonucleotide stability
- MeSH terms
- Humans, Oligonucleotides, Antisense, Gene Transfer Techniques, Gene Silencing, RNA, Small Interfering, MicroRNAs, Nanoparticles
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