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In Vitro Antioxidant Activities of Phenols and Oleanolic Acid from Mango Peel and Their Cytotoxic Effect on A549 Cell Line
Open accessAbstract
Mango peel, the main by-product of juice processing, possesses appreciable quantities of bioactive phenolic compounds and is worthy of further utilization. The present work reports for the first time the HPLC analysis and in vitro antioxidant evaluation of mango peel phenols (MPPs) and their cytotoxic effect on the A549 lung cancer cell line. These results indicated that mango peel has the total phenolic content of 723.2 ± 0.93 mg·kg−1 dry mango peel (DMP), which consisted mainly of vanillic aldehyde, caffeic acid, chlorogenic acid, gallic acid, procyanidin B2 and oleanolic acid. Antioxidant assays showed that MPPs had strong antioxidant activities, with 92 ± 4.2% of DPPH radical scavenging rate, 79 ± 2.5% of ABTS radical inhibition rate and 4.7 ± 0.5 μM Trolox equivalents per kg−1 DMP of ferric reducing power. Gallic acid possess a stronger antioxidant capacity than other phenols. In vitro cytotoxic tests suggested that mango peel extract (MPE) had an IC50 value of 15 mg·mL−1 and MPPs had a stronger inhibitory effect on the A549 cell line. Oleanolic acid exhibited the strongest cytotoxicity, with an IC50 value of 4.7 μM, which was similar with that of the positive control 5-fluorouracil.
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“Another study also reported higher capacity to inhibit ABTS compared to DPPH in mango peel extract [20].”
From On the Path to Sustainable Cosmetics: Development of a Value-Added Formulation of Solid Shampoo Incorporating Mango Peel Extract (2023) · cites this paper as [20]
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References 20 · Cited by 54
Research works printed but not linked: 1
- Ndoye, 2018, Antioxidant and antiglycation properties of two mango (Mangifera indica L.) cultivars from Senegal, Asian Pac. J. Trop. Biomed., 3, 137
Metadata
- Authors
- Bai, X., Lai, T., Zhou, T., Li, Y., Li, X., & Zhang, H.
- Affiliations
- Hangzhou Normal University (CN)
- Beijing Technology and Business University (CN)
- Zhejiang University of Technology (CN)
- Corresponding author
- Li, Xiuting
- Zhang, Huawei
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2018-06-08
- Volume
- 23
- Issue
- 6
- Pages
- 1395
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC6100009
- OpenAlex
- W2805089831
- Cited by
- 54
- References
- 20
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 9 · 2023: 4 · 2022: 8 · 2021: 11 · 2020: 5 · 2019: 9
- FWCI
- 8.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Beijing Advanced Innovation Center for Food Nutrition and Human Health (2016)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- mango peel, phenolic compounds, oleanolic acid, antioxidant activity, cytotoxicity, A549 cells, lung cancer, gallic acid, chlorogenic acid, caffeic acid, procyanidin B2, fruit by-products, DPPH radical scavenging, ferric reducing power
- MeSH terms
- A549 Cells, Antineoplastic Agents, Phytogenic, Antioxidants, Chromatography, High Pressure Liquid, Humans, Oleanolic Acid, Phenols, Plant Structures, Inhibitory Concentration 50, Mangifera
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