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Cited by 28biodegradable polymer synthesis and propertiesPolymer Surface Interaction StudiesMagnesium Alloys: Properties and Applications

Degradation Behavior of Poly(Lactide-Co-Glycolide) Monolayers Investigated by Langmuir Technique: Accelerating Effect

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Kim, Gayeon, Gavande, Vishal, Shaikh, Vasi, Lee, Won-Ki·2023·Molecules
DOI 10.3390/molecules28124810PMC PMC10302801
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Abstract

Among biodegradable polymers, polylactides (PLAs) have attracted considerable interest because the monomer can be produced from renewable resources. Since their initial degradability strongly affects commercial application fields, it is necessary to manage the degradation properties of PLAs to make them more commercially attractive. To control their degradability, poly(lactide-co-glycolide) (PLGA) copolymers of glycolide and isomer lactides (LAs) were synthesized, and their enzymatic and alkaline degradation rates of PLGA monolayers as functions of glycolide acid (GA) composition were systematically investigated by the Langmuir technique. The results showed that the alkaline and enzymatic degradations of PLGA monolayers were faster than those of l-polylactide (l-PLA), even though proteinase K is selectively effective in the l-lactide (l-LA) unit. Alkaline hydrolysis was strongly affected by their hydrophilicity, while the surface pressure of monolayers for enzymatic degradations was a major factor.

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  • Polymeric films (PLA/PLGA), such as polylactide sheets or meshes used experimentally or with meshes, degrade by hydrolysis over 6-8 weeks, releasing lactic/glycolic acid monomers.

    “Polymeric films (PLA/PLGA)—e.g., polylactide sheets or meshes used experimentally or in combination with meshes; these degrade by hydrolysis over 6-8 weeks, releasing lactic/glycolic acid monomers [268].”

    From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [268]

    The Introduction states that PLGA breaks down by hydrolysis into lactic and glycolic acids. It does not establish a 6–8-week degradation period for PLA/PLGA films, sheets, or meshes; instead, it gives approximately ten months for complete PLA biodegradation and notes that degradation rates vary. (LLM, conf=0.90)

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Cited by

Sorted by citations

Authors
Kim, G., Gavande, V., Shaikh, V., & Lee, W.-K.
Affiliations
  • Pukyong National University (KR)
  • MIT World Peace University (IN)
Corresponding author
Lee, Won-Ki
ORCID
Venue
Molecules
Publisher
MDPI AG
Published
2023-06-16
Volume
28
Issue
12
Pages
4810
ISSN
1420-3049 (ISSN-L)
DOI
10.3390/molecules28124810
PMC
PMC10302801
OpenAlex
W4380987474
Cited by
28
References
2
Citations by year
2026: 11 · 2025: 10 · 2024: 6 · 2023: 1
FWCI
1.74
Type
journal article
Language
en
Open access
Licence
Locations
  • Molecules (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Ministry of Trade, Industry and Energy (20010519)
Topics
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
  • Physical Sciences › Materials Science › Biomaterials › Magnesium Alloys: Properties and Applications
Keywords
poly(lactic-co-glycolic acid), polymer degradation, enzymatic degradation, alkaline hydrolysis, proteinase K, surface pressure, hydrophilicity, biodegradable polymers, Langmuir monolayers

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