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Cited by 7Analytical chemistry methods developmentPharmaceutical and Antibiotic Environmental ImpactsPesticide Residue Analysis and Safety

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Dendrimer Coated Silica as a Sorbent for Dispersive Solid-Phase Extraction of Select Non-Steroidal Anti-Inflammatory Drugs from Water

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Ścigalski, Piotr, Kosobucki, Przemysław·2024·Molecules
DOI 10.3390/molecules29020380PMC PMC10819187
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Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) have been recognized as a potentially serious threat to the natural environment. NSAIDs are popular painkillers, and the main pathway for them to reach natural water is via discharge from wastewater and sewage treatment plants. In order to monitor contamination caused by these drugs, as well as their impact on the environment, a new material based on Silica Gel 60, functionalized with a dendrimeric copolymer of methylamine and 1,4-butanediol diglycidyl ether (named MA-BDDE), was prepared. Initial physicochemical characterization of the MA-BDDE material was carried out using ATR FT-IR spectroscopy as well as solid-state carbon-13 NMR spectroscopy. Its effectiveness at NSAID extraction was evaluated by the application of five select drugs in dispersive solid-phase extraction (dSPE): aspirin, ketoprofen, naproxen, diclofenac and ibuprofen. This was followed by their simultaneous determination using the HPLC-UV/Vis system demonstrating good sensitivity, with limits of detection values within the 63–265 ng mL−1 range. A comparison of the sorption capacity of each pharmaceutical with unmodified base silica showed an at least tenfold increase in capacity after modification. Initial MA-BDDE application in a quick, low-waste extraction procedure of those select NSAIDs from spiked surface water samples yielded promising results for its use as a sorbent, as recovery values of analytes adsorbed from various samples were found to exceed 72%.

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Metadata

Authors
Ścigalski, P., & Kosobucki, P.
Affiliations
Bydgoszcz University of Science and Technology (PL)
ORCID
Venue
Molecules
Publisher
MDPI AG
Published
2024-01-12
Volume
29
Issue
2
Pages
380
ISSN
1420-3049 (ISSN-L)
DOI
10.3390/molecules29020380
PMC
PMC10819187
OpenAlex
W4390819958
Cited by
7
References
32
Citations by year
2026: 3 · 2025: 2 · 2024: 2
FWCI
0.90
Type
journal article
Language
en
Open access
Licence
Locations
  • Molecules (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Physical Sciences › Chemistry › Analytical Chemistry › Analytical chemistry methods development
  • Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Pesticide Residue Analysis and Safety
Keywords
nonsteroidal anti-inflammatory drugs, silica gel adsorbent, dispersive solid-phase extraction, pharmaceuticals in water, aspirin, ketoprofen, naproxen, diclofenac, ibuprofen, wastewater discharge, surface water contamination, sorption capacity
MeSH terms
Anti-Inflammatory Agents, Non-Steroidal, Aspirin, Diclofenac, Spectroscopy, Fourier Transform Infrared, Dendrimers

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