Enhancing Drug Solubility, Bioavailability, and Targeted Therapeutic Applications through Magnetic Nanoparticles
Open accessAbstract
Biological variability poses significant challenges in the development of effective therapeutics, particularly when it comes to drug solubility and bioavailability. Poor solubility across varying physiological conditions often leads to reduced absorption and inconsistent therapeutic outcomes. This review examines how nanotechnology, especially through the use of nanomaterials and magnetic nanoparticles, offers innovative solutions to enhance drug solubility and bioavailability. This comprehensive review focuses on recent advancements and approaches in nanotechnology. We highlight both the successes and remaining challenges in this field, emphasizing the role of continued innovation. Future research should prioritize developing universal therapeutic solutions, conducting interdisciplinary research, and leveraging personalized nanomedicine to address biological variability.
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Advanced drug delivery platforms can improve solubility, stability, bioavailability, and site-specific targeting, increasing treatment efficacy while minimizing systemic exposure.
“More broadly, advanced drug delivery platforms can improve solubility [22], stability [23], bioavailability [24], and site‐specific targeting [25], ultimately increasing treatment efficacy while minimizing systemic exposure.”
From Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology-Driven Delivery Strategies (2025) · cites this paper as [22]
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References 101 · Cited by 180
- Authors
- Zhuo, Y., Zhao, Y.-G., & Zhang, Y.
- Affiliations
- South China University of Technology (CN)
- Zhejiang Shuren University (CN)
- NingboTech University (CN)
- Corresponding author
- Zhao, Yong-Gang
- Zhang, Yun
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2024-10-13
- Volume
- 29
- Issue
- 20
- Pages
- 4854
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC11510236
- OpenAlex
- W4403380622
- Cited by
- 180
- References
- 101
- Citations by year
- 2026: 81 · 2025: 95 · 2024: 4
- FWCI
- 5.09
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Zhejiang Provincial Key Research and Development Project (2024C03231, KXJ0522109, 2023J277, KF202304, NBTJG-202253)
- the Talents Program of Zhejiang Shuren University (2024C03231, KXJ0522109, 2023J277, KF202304, NBTJG-202253)
- Natural Science Foundation of Ningbo (2024C03231, KXJ0522109, 2023J277, KF202304, NBTJG-202253)
- Ningbo Key Laboratory of Testing and Control for Characteristic Agro-Product Quality and Safety (2024C03231, KXJ0522109, 2023J277, KF202304, NBTJG-202253)
- the teaching reform research project of NingboTech. University (2024C03231, KXJ0522109, 2023J277, KF202304, NBTJG-202253)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Pharmacology and Nanomedicine Research
- Keywords
- magnetic nanoparticles, drug solubility, bioavailability, nanomedicine, drug delivery, nanomaterials, personalized medicine, biological variation, targeted therapy
- MeSH terms
- Animals, Biological Availability, Drug Carriers, Pharmaceutical Preparations, Humans, Solubility, Drug Delivery Systems, Nanotechnology, Nanomedicine, Magnetite Nanoparticles
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