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Cited by 258

The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.

Sarcopenia and Heart Failure

Open access
Curcio, Francesco, Testa, Gianluca, Liguori, Ilaria, Papillo, Martina, Flocco, Veronica, Panicara, Veronica, Galizia, Gianluigi, Della-Morte, David, Gargiulo, Gaetano, Cacciatore, Francesco, Bonaduce, Domenico, Landi, Francesco, Abete, Pasquale·2020·Nutrients

Abstract

Modifications of lean mass are a frequent critical determinant in the pathophysiology and progression of heart failure (HF). Sarcopenia may be considered one of the most important causes of low physical performance and reduced cardiorespiratory fitness in older patients with HF. Sarcopenia is frequently misdiagnosed as cachexia. However, muscle wasting in HF has different pathogenetic features in sarcopenic and cachectic conditions. HF may induce sarcopenia through common pathogenetic pathways such as hormonal changes, malnutrition, and physical inactivity; mechanisms that influence each other. In the opposite way, sarcopenia may favor HF development by different mechanisms, including pathological ergoreflex. Paradoxically, sarcopenia is not associated with a sarcopenic cardiac muscle, but the cardiac muscle shows a hypertrophy which seems to be “not-functional.” First-line agents for the treatment of HF, physical activity and nutritional interventions, may offer a therapeutic advantage in sarcopenic patients irrespective of HF. Thus, sarcopenia is highly prevalent in patients with HF, contributing to its poor prognosis, and both conditions could benefit from common treatment strategies based on pharmacological, physical activity, and nutritional approaches.

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Registry

Crossref · 10.3390/nu12010211

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Metadata

Authors
Curcio, F., Testa, G., Liguori, I., Papillo, M., Flocco, V., Panicara, V., Galizia, G., Della-Morte, D., Gargiulo, G., Cacciatore, F., Bonaduce, D., Landi, F., & Abete, P.
Venue
Nutrients
Publisher
MDPI AG
Published
2020-01-14
Volume
12
Issue
1
Pages
211
ISSN
2072-6643 (ISSN-L)
OpenAlex
W2999115344
Cited by
258
References
92
FWCI
17.22
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Sarcopenia and Heart Failure. https://app.cochat.ai/papers/10.3390/nu12010211
The paper
Curcio, F., Testa, G., Liguori, I., Papillo, M., Flocco, V., Panicara, V., Galizia, G., Della-Morte, D., Gargiulo, G., Cacciatore, F., Bonaduce, D., Landi, F., & Abete, P. (2020). Sarcopenia and Heart Failure. Nutrients. https://doi.org/10.3390/nu12010211

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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