The Extract of Arctium lappa L. Fruit (Arctii Fructus) Improves Cancer-Induced Cachexia by Inhibiting Weight Loss of Skeletal Muscle and Adipose Tissue
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Background: Cachexia induced by cancer is a systemic wasting syndrome and it accompanies continuous body weight loss with the exhaustion of skeletal muscle and adipose tissue. Cancer cachexia is not only a problem in itself, but it also reduces the effectiveness of treatments and deteriorates quality of life. However, effective treatments have not been found yet. Although Arctii Fructus (AF) has been studied about several pharmacological effects, there were no reports on its use in cancer cachexia. Methods: To induce cancer cachexia in mice, we inoculated CT-26 cells to BALB/c mice through subcutaneous injection and intraperitoneal injection. To mimic cancer cachexia in vitro, we used conditioned media (CM), which was CT-26 colon cancer cells cultured medium. Results: In in vivo experiments, AF suppressed expression of interleukin (IL)-6 and atrophy of skeletal muscle and adipose tissue. As a result, the administration of AF decreased mortality by preventing weight loss. In adipose tissue, AF decreased expression of uncoupling protein 1 (UCP1) by restoring AMP-activated protein kinase (AMPK) activation. In in vitro model, CM increased muscle degradation factors and decreased adipocytes differentiation factors. However, these tendencies were ameliorated by AF treatment in C2C12 myoblasts and 3T3-L1 cells. Conclusion: Taken together, our study demonstrated that AF could be a therapeutic supplement for patients suffering from cancer cachexia.
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Arctium lappa L. fruit extract improves cancer-induced muscle atrophy by inhibiting skeletal muscle loss in BALB/c mice.
“The Arctium lappa L. fruit extract rich in arctiin and arctigenin improves cancer-induced muscle atrophy by inhibiting skeletal muscle loss in BALB/c mice.”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [157]
In C2C12 myoblasts and 3T3-L1 cells, Arctium lappa L. fruit extract decreases the expression of muscle degradation factors (MAFbx and MuRF1) and increases adipocytes differentiation factors, respectively.
“In C2C12 myoblasts and 3T3-L1 cells, it decreases the expression of muscle degradation factors (MAFbx and MuRF1) and increases adipocytes differentiation factors, respectively [157].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [157]
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References 57 · Cited by 24
- Authors
- Han, Y.-H., Mun, J.-G., Jeon, H. D., Yoon, D. H., Choi, B.-M., Kee, J.-Y., & Hong, S.-H.
- Affiliations
- Department of Oriental Pharmacy, College of Pharmacy, Wonkwang-Oriental Medicines Research Institute, Wonkwang University, Iksan, Jeonbuk 54538, Korea
- Wonkwang University (KR)
- Corresponding author
- Kee, Ji-Ye
- Hong, Seung-Heon
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2020-10-19
- Volume
- 12
- Issue
- 10
- Pages
- 3195
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC7603378
- OpenAlex
- W3093244269
- Cited by
- 24
- References
- 57
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 8 · 2022: 5 · 2021: 3
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Research Foundation of Korea (2018R1C1B6002722, 2018R1D1A3B07040871, 2019R1I1A3A01060998)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- Arctium lappa, cancer cachexia, skeletal muscle atrophy, adipose tissue atrophy, weight loss, interleukin-6, UCP1, AMPK, muscle degradation, adipogenesis, conditioned medium, plant extracts
- MeSH terms
- Uncoupling Protein 1, Adipose Tissue, Animals, Atrophy, Cachexia, Male, Phytotherapy, Mice, Inbred BALB C, Neoplasms, Plant Extracts, Tumor Cells, Cultured, Weight Loss, Interleukin-6, Gene Expression, Muscle, Skeletal, Arctium, 3T3-L1 Cells, Mice, AMP-Activated Protein Kinases
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