The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Beneficial Outcomes of Omega-6 and Omega-3 Polyunsaturated Fatty Acids on Human Health: An Update for 2021
Open accessAbstract
Oxidative stress and inflammation have been recognized as important contributors to the risk of chronic non-communicable diseases. Polyunsaturated fatty acids (PUFAs) may regulate the antioxidant signaling pathway and modulate inflammatory processes. They also influence hepatic lipid metabolism and physiological responses of other organs, including the heart. Longitudinal prospective cohort studies demonstrate that there is an association between moderate intake of the omega-6 PUFA linoleic acid and lower risk of cardiovascular diseases (CVDs), most likely as a result of lower blood cholesterol concentration. Current evidence suggests that increasing intake of arachidonic acid (up to 1500 mg/day) has no adverse effect on platelet aggregation and blood clotting, immune function and markers of inflammation, but may benefit muscle and cognitive performance. Many studies show that higher intakes of omega-3 PUFAs, especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are associated with a lower incidence of chronic diseases characterized by elevated inflammation, including CVDs. This is because of the multiple molecular and cellular actions of EPA and DHA. Intervention trials using EPA + DHA indicate benefit on CVD mortality and a significant inverse linear dose–response relationship has been found between EPA + DHA intake and CVD outcomes. In addition to their antioxidant and anti-inflammatory roles, omega-3 fatty acids are considered to regulate platelet homeostasis and lower risk of thrombosis, which together indicate their potential use in COVID-19 therapy.
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Cites
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“GPR120 is a plasma membrane G protein coupled receptor (also 477 called free fatty acid receptor 4) that is able to bind long-chain fatty acids, especially DHA 478 [151].”
InfluentialOmega-3 fatty acids and inflammatory processes: from molecules to man
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Self-citationResolvins in inflammation: emergence of the pro-resolving superfamily of mediators
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Cited by
Targeting Oxidative Stress Involved in Endometriosis and Its Pain
Clower, L., Fleshman, T., Geldenhuys, W. J., & Santanam, N. (2022) · Biomolecules · doi:10.3390/biom12081055 · Cited by 145
“Deficiencies in the active form of vitamin D correlate with an increased risk for coronary heart disease and can result in increased mortality rates, whereas omega-3 fatty acids or fish oil supplements have commonly been used to reduce mortality rates in cardiovascular diseases [122,123].”
BackgroundFekete, M., Szarvas, Z., Fazekas-Pongor, V., Feher, A., Csipo, T., Forrai, J., Dosa, N., Peterfi, A., Lehoczki, A., Tarantini, S., et al. (2022) · Nutrients · doi:10.3390/nu15010047 · Cited by 137
Javaid, M., Kadhim, K., Bawamia, B., Cartlidge, T., Farag, M., & Alkhalil, M. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.123.032390 · Cited by 58
Farag, M. A., Reda, A., Nabil, M., Elimam, D. M., & Zayed, A. (2023) · Food & Function · doi:10.1039/d3fo01949g · Cited by 28
Tavakoli, Z., Kavoosi, G., Siahbalaei, R., & Karimi, J. (2025) · Applied Food Research · doi:10.1016/j.afres.2025.100741 · Cited by 27
Metadata
- Authors
- Djuricic, I., & Calder, P. C.
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2021-07-15
- Volume
- 13
- Issue
- 7
- Pages
- 2421
- ISSN
- 2072-6643 (ISSN-L)
- OpenAlex
- W3181573421
- Cited by
- 1,015
- References
- 42
- FWCI
- 77.60
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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