Antioxidant Effect of Coenzyme Q10 in the Prevention of Oxidative Stress in Arsenic-Treated CHO-K1 Cells and Possible Participation of Zinc as a Pro-Oxidant Agent
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Oxidative stress is an imbalance between levels of reactive oxygen species (ROS) and antioxidant enzymes. Compounds with antioxidant properties, such as coenzyme Q10 (CoQ10), can reduce cellular imbalance caused by an increase in ROS. CoQ10 participates in modulating redox homeostasis due to its antioxidant activity and its preserving mitochondrial functions. Thus, the present study demonstrated the protective effects of CoQ10 against oxidative stress and cytotoxicity induced by arsenic (As). Antioxidant capacity, formation of hydroperoxides, generation of ROS, and the effect on cellular viability of CoQ10, were investigated to determine the protective effect of CoQ10 against As and pro-oxidant compounds, such as zinc. Cell viability assays showed that CoQ10 is cytoprotective under cellular stress conditions, with potent antioxidant activity, regardless of the concentration tested. Zn, when used at higher concentrations, can increase ROS and show a pro-oxidant effect causing cell damage. The cytotoxic effect observed for As, Zn, or the combination of both could be prevented by CoQ10, without any decrease in its activity at cellular levels when combined with Zn.
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Coenzyme Q10 protects phospholipids of cell membranes and intracellular membranes from peroxidation.
“It is also found in the cell membrane and represents a principal molecule in the maintenance of the antioxidant system for protecting phospholipids of membranes from peroxidation, acting as a membrane stabilizer for the cell membrane and all intracellular membranes.”
From Can coenzyme Q10 alleviate the toxic effect of fenofibrate on skeletal muscle? (2023) · cites this paper as Silva et al. 2022
The Introduction (page unavailable) says CoQ10 protects against lipid peroxidation and acts as a membrane stabilizer. It does not specify phospholipids or say that this protection extends to all intracellular membranes. (LLM, conf=0.83)
Experimental — accuracy not yet measuredCoenzyme Q10 protects membrane proteins and DNA against oxidative damage.
“In addition, it can protect membrane proteins and deoxyribonucleic acid (DNA) against oxidative damage (Silva et al. 2022).”
From Can coenzyme Q10 alleviate the toxic effect of fenofibrate on skeletal muscle? (2023) · cites this paper as Silva et al. 2022
The Introduction states that CoQ10 inhibits protein oxidation and DNA damage and acts as a membrane stabilizer. It does not specifically identify membrane proteins as the proteins protected, so the claim is more specific than the passage supports. (LLM, conf=0.82)
Experimental — accuracy not yet measuredCoenzyme Q10 has demonstrated therapeutic benefits in aging-related disorders and in mitigation of heavy metal toxicities due to anti-inflammatory, antioxidant, and antiapoptotic properties.
“Therapeutic benefits of CoQ10 were demonstrated in aging-related disorders, mainly those accompanied by increased oxidative stress (Diaz-Casado et al. 2019) and in the mitigation of heavy metal toxicities from lead and arsenic due to its antiinflammatory, antioxidant, and antiapoptotic properties (Al-Megrin et al. 2020; Silva et al. 2022).”
From Can coenzyme Q10 alleviate the toxic effect of fenofibrate on skeletal muscle? (2023) · cites this paper as Silva et al. 2022
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References 65 · Cited by 35
- Authors
- Silva, S. V. E., Gallia, M. C., Luz, J. R. D. D., Rezende, A. A. D., Bongiovanni, G. A., Araujo-Silva, G., & Almeida, M. D. G.
- Affiliations
- Universidade Federal do Rio Grande do Norte (BR)
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Organic Chemistry and Biochemistry Laboratory, State University of Amapá (UEAP), Macapá 68900070, Brazil
- Corresponding author
- Almeida, Maria das Graças
- ORCID
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2022-08-10
- Volume
- 14
- Issue
- 16
- Pages
- 3265
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC9412518
- OpenAlex
- W4293680142
- Cited by
- 35
- References
- 65
- Citations by year
- 2026: 6 · 2025: 15 · 2024: 7 · 2023: 7
- FWCI
- 2.37
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Research Group of Guillermina Azucena Bongiovanni (PIP 0239-CONICET)
- Becas de Integración Regional para ciudadanos de Latinoamérica y El Caribe—Convocatoria 2019 (PIP 0239-CONICET)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Keywords
- coenzyme Q10, oxidative stress, arsenic toxicity, zinc, pro-oxidant activity, reactive oxygen species, hydroperoxides, redox homeostasis, mitochondrial function, cytotoxicity, CHO-K1 cells, antioxidant activity, cell viability
- MeSH terms
- Antioxidants, Arsenic, Ubiquinone, Zinc, Reactive Oxygen Species, Oxidative Stress
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