Effect of Chia (Salvia hispanica L.) Associated with High-Fat Diet on the Intestinal Health of Wistar Rats
Open accessAbstract
A direct correlation has been reported between excessive fat intake and the development and progression of various enteropathies. Plant foods may contain bioactive compounds and non-digestible dietary fiber, with potential to improve intestinal health. Chia is a good source of dietary fiber and bioactive compounds. Our study evaluated the role of chia flour associated with a high-fat diet (HFD) on colon histomorphometry, intestinal functionality and intestinal microbiome composition and function in Wistar rats. The study used 32 young male rats separated into four groups to receive a standard diet (SD) or HFD, with or without chia, for 35 days. At the end of the study, the cecum, cecal content and duodenum were collected. The consumption of chia increased the production of short-chain fatty acids and improved fecal moisture. Chia consumption improved the circular muscle layer in the SD group. The diversity and abundance of intestinal bacteria were not affected, but increased richness was observed in the microbiome of the SD+chia group. Moreover, chia consumption decreased the expression of proteins involved in intestinal functionality. Chia consumption improved intestinal morphology and functionality in young Wistar rats but was insufficient to promote significant changes in the intestinal microbiome in a short term of 35 days.
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Both quinoa and chia seeds are gluten-free and provide medicinal properties due to bioactive compounds, which help combat various chronic diseases such as diabetes, obesity, cardiovascular diseases, and metabolic diseases such as cancer.
“Both quinoa and chia seeds are gluten-free and provide medicinal properties due to bioactive compounds, which help combat various chronic diseases such as diabetes, obesity, cardiovascular diseases, and metabolic diseases such as cancer”
From Nutritional and Functional New Perspectives and Potential Health Benefits of Quinoa and Chia Seeds (2023) · cites this paper as [13]
S. hispanica L. and C. quinoa L. contain significantly more nutrients and bioactive components than other grains and are valuable against physiological disorders like diabetes, hypertension, cardiovascular diseases, and obesity.
“Because they contain significantly more nutrients and bioactive components than other grains, they are excellent and valuable against physiological disorders like diabetes, hypertension, cardiovascular diseases, and obesity [13,15,26].”
From Nutritional and Functional New Perspectives and Potential Health Benefits of Quinoa and Chia Seeds (2023) · cites this paper as [13]
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References 53 · Cited by 23
- Authors
- Mishima, M. D. V., Da Silva, B. P., Gomes, M. J. C., Toledo, R. C. L., Mantovani, H. C., José, V. P. B. D. S., Costa, N. M. B., Tako, E., & Martino, H. S. D.
- Affiliations
- Universidade Federal de Viçosa (BR)
- Department of Nutrition and Health, Federal University of Viçosa, Av. Purdue, s/n, Campus Universitário, Viçosa 36570-900, MG, Brazil
- Universidade Federal do Espírito Santo (BR)
- Cornell University (US)
- Corresponding author
- Martino, Hércia Stampini Duarte
- ORCID
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2022-11-21
- Volume
- 14
- Issue
- 22
- Pages
- 4924
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC9696280
- OpenAlex
- W4309710780
- Cited by
- 23
- References
- 53
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 3 · 2023: 7
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (88887.599144/2021-00, 88887, 2021-00, 2018-5)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (310910/2020-0, 24/2018, 406517/2018-5)
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais (APQ-02183-17)
- Fundação de Amparo à Pesquisa e Inovação do Espírito Santo (24/2018 ?, TO 567/2018, 567/2018)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Life Sciences › Agricultural and Biological Sciences › Food Science › Seed and Plant Biochemistry
- Keywords
- chia, Salvia hispanica, high-fat diet, gut health, short-chain fatty acids, fecal moisture, gut microbiota, dietary fiber, bioactive compounds, intestinal function, Wistar rats
- MeSH terms
- Salvia hispanica, Animals, Dietary Fiber, Seeds, Rats, Wistar, Salvia, Rats, Diet, High-Fat
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