The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease
Open accessAbstract
Non-alcoholic fatty liver disease is marked by hepatic fat accumulation not due to alcohol abuse. Several studies have demonstrated that NAFLD is associated with insulin resistance leading to a resistance in the antilipolytic effect of insulin in the adipose tissue with an increase of free fatty acids (FFAs). The increase of FFAs induces mitochondrial dysfunction and development of lipotoxicity. Moreover, in subjects with NAFLD, ectopic fat also accumulates as cardiac and pancreatic fat. In this review we analyzed the mechanisms that relate NAFLD with metabolic syndrome and dyslipidemia and its association with the development and progression of cardiovascular disease.
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Nonalcoholic Fatty Liver Disease
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Self-citationRisk of Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver Disease
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Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity
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Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance
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Self-citationOverproduction of large VLDL particles is driven by increased liver fat content in man
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Cited by
EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease
(2016) · Journal of Hepatology · doi:10.1016/j.jhep.2015.11.004 · Cited by 4,836
Non-alcoholic fatty liver disease - a global public health perspective
Younossi, Z. M. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2018.10.033 · Cited by 2,149
Tilg, H., Moschen, A. R., & Roden, M. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.147 · Cited by 1,002
Mechanisms Linking Inflammation to Insulin Resistance
Chen, L., Chen, R., Wang, H., & Liang, F. (2015) · International Journal of Endocrinology · doi:10.1155/2015/508409 · Cited by 644
The Liver as an Endocrine Organ—Linking NAFLD and Insulin Resistance
Watt, M. J., Miotto, P. M., De Nardo, W., & Montgomery, M. K. (2019) · Endocrine Reviews · doi:10.1210/er.2019-00034 · Cited by 615
Metadata
- Authors
- Gaggini, M., Morelli, M., Buzzigoli, E., DeFronzo, R., Bugianesi, E., & Gastaldelli, A.
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2013-05-10
- Volume
- 5
- Issue
- 5
- Pages
- 1544-1560
- ISSN
- 2072-6643 (ISSN-L)
- OpenAlex
- W1996067821
- Cited by
- 822
- References
- 20
- FWCI
- 36.75
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease. https://app.cochat.ai/papers/10.3390/nu5051544
- The paper
- Gaggini, M., Morelli, M., Buzzigoli, E., DeFronzo, R., Bugianesi, E., & Gastaldelli, A. (2013). Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease. Nutrients. https://doi.org/10.3390/nu5051544
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
