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Cited by 102Celiac Disease Research and ManagementFood composition and propertiesWheat and Barley Genetics and Pathology

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The Gluten-Free Diet: Testing Alternative Cereals Tolerated by Celiac Patients

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Comino, Isabel, De Lourdes Moreno, María, Real, Ana, Rodríguez-Herrera, Alfonso, Barro, Francisco, Sousa, Carolina·2013·Nutrients
DOI 10.3390/nu5104250PMC PMC3820072
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Abstract

A strict gluten-free diet (GFD) is the only currently available therapeutic treatment for patients with celiac disease, an autoimmune disorder of the small intestine associated with a permanent intolerance to gluten proteins. The complete elimination of gluten proteins contained in cereals from the diet is the key to celiac disease management. However, this generates numerous social and economic repercussions due to the ubiquity of gluten in foods. The research presented in this review focuses on the current status of alternative cereals and pseudocereals and their derivatives obtained by natural selection, breeding programs and transgenic or enzymatic technology, potential tolerated by celiac people. Finally, we describe several strategies for detoxification of dietary gluten. These included enzymatic cleavage of gliadin fragment by Prolyl endopeptidases (PEPs) from different organisms, degradation of toxic peptides by germinating cereal enzymes and transamidation of cereal flours. This information can be used to search for and develop cereals with the baking and nutritional qualities of toxic cereals, but which do not exacerbate this condition.

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  • Gluten is found in all wheat, barley (including malted barley), rye, spelt, and Khorasan wheat (kamut®) varieties and its derivates.

    “Gluten is found in all wheat, barley (including malted barley), rye, spelt, and Khorasan wheat (kamut®) varieties and its derivates (Figure 1) (10).”

    From Gluten-free diet for pediatric patients with coeliac disease: A position paper from the ESPGHAN gastroenterology committee, special interest group in coeliac disease. (2024) · cites this paper as [10]

    The Introduction (page unavailable) identifies gluten in wheat, barley and rye, supporting the core of the claim. Section 2.1 (page unavailable) discusses variation among wheat and barley lines, but our copy does not establish the claim for all varieties or specifically address spelt, Khorasan wheat (kamut®), or derivatives. (LLM, conf=0.85)

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Authors
Comino, I., De Lourdes Moreno, M., Real, A., Rodríguez-Herrera, A., Barro, F., & Sousa, C.
Affiliations
  • Universidad de Sevilla (ES)
  • Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad de Sevilla, c/Profesor García González 2, 41012 Sevilla, Spain
  • Instituto Hispalense de Pediatría, c/Guadalbullón 2, 41013 Sevilla, Spain
  • Consejo Superior de Investigaciones Científicas (ES)
Corresponding author
Sousa, Carolina
ORCID
Venue
Nutrients
Publisher
MDPI AG
Published
2013-10-23
Volume
5
Issue
10
Pages
4250-4268
ISSN
2072-6643 (ISSN-L)
DOI
10.3390/nu5104250
PMC
PMC3820072
OpenAlex
W2030810018
Cited by
102
References
0
Citations by year
2026: 6 · 2025: 5 · 2024: 7 · 2023: 13 · 2022: 5 · 2021: 11 · 2020: 10 · 2019: 9 · 2018: 12 · 2017: 11 · 2016: 6 · 2015: 6 · 2013: 1
FWCI
0.69
Type
journal article
Language
en
Open access
Licence
Locations
  • Nutrients (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, cc-by-nc-nd)
  • Deposito de Investigacion Universidad de Sevilla (University of Seville) (publishedVersion, cc-by-nc-nd)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Deposito de Investigacion Universidad de Sevilla (University of Seville) (submittedVersion, cc-by-nc-nd)
Topics
  • Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
  • Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Wheat and Barley Genetics and Pathology
Keywords
gluten-free diet, celiac disease, alternative grains, pseudocereals, prolyl endopeptidase, gliadin, transamidation, cereal breeding, gluten intolerance
MeSH terms
Prolyl Oligopeptidases, Celiac Disease, Edible Grain, Gliadin, Humans, Intestine, Small, Serine Endopeptidases, Diet, Gluten-Free

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