Hypothiocyanite and Hypothiocyanite/Lactoferrin Mixture Exhibit Virucidal Activity In Vitro against SARS-CoV-2
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Abstract
SARS-CoV-2 replicates efficiently in the upper airways during the prodromal stage, resulting in environmental viral shedding from patients with active COVID-19 as well as from asymptomatic individuals. There is a need to find pharmacological interventions to mitigate the spread of COVID-19. Hypothiocyanite and lactoferrin are molecules of the innate immune system with a large spectrum cidal activity. The Food and Drug Administration and the European Medicines Agency designated the hypothiocyanite and lactoferrin combination as an orphan drug. We report an in vitro study showing that micromolar concentrations of hypothiocyanite exhibit dose- and time-dependent virucidal activity against SARS-CoV-2 and that the latter is slightly enhanced by the simultaneous presence of lactoferrin.
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OSCN− is able to oxidize the capsid proteins of respiratory viruses by creating disulphide bonds in the free thiol radicals of proteins.
“OSCN− is able to oxidize the capsid proteins of respiratory viruses by creating disulphide bonds in the free thiol radicals of proteins [174].”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [174]
A laboratory experiment against the 2009 A/H1N1 pandemic influenza virus showed clear virucidal activity of OSCN−, dose-dependent and without any cytotoxic effect.
“A laboratory experiment against the 2009 A/H1N1 pandemic influenza virus showed clear virucidal activity of OSCN-, dose-dependent and without any cytotoxic effect.”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [174]
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References 44 · Cited by 30
- Authors
- Cegolon, L., Mirandola, M., Salaris, C., Salvati, M. V., Mastrangelo, G., & Salata, C.
- Affiliations
- AULSS 2 Marca Trevigiana (IT)
- University of Padua (IT)
- Corresponding author
- Cegolon, Luca
- Salata, Cristiano
- Venue
- Pathogens
- Publisher
- MDPI AG
- Published
- 2021-02-19
- Volume
- 10
- Issue
- 2
- Pages
- 233
- ISSN
- 2076-0817 (ISSN-L)
- PMC
- PMC7922920
- OpenAlex
- W3130703392
- Cited by
- 30
- References
- 44
- Citations by year
- 2025: 1 · 2024: 6 · 2023: 7 · 2022: 10 · 2021: 6
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Pathogens (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nd)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/) (submittedVersion, cc-by)
- ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Padua Research Archive (University of Padova) (submittedVersion, cc-by)
- Funders
- Università degli Studi di Padova (DOR-2019 and DOR-2020)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Keywords
- hypothiocyanite, lactoferrin, SARS-CoV-2, virucidal activity, COVID-19 pandemic, antiviral agents, innate immunity, combination therapy, orphan drugs, viral shedding
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